caa a22 4500 60623960X CHVBK 20210128101304.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00508-014-0640-3 doi (NATIONALLICENCE)springer-10.1007/s00508-014-0640-3 Gender, metabolic control and carotid intima-media-thickness in children and adolescents with type 1 diabetes mellitus [Elektronische Daten] [Georgiana-Aura Giurgea, Katrin Nagl, Michael Gschwandtner, Clemens Höbaus, Thomas Hörtenhuber, Renate Koppensteiner, Christian Margeta, Maria Fritsch, Birgit Rami-Merhar, Gerit-Holger Schernthaner, Oliver Schlager, Edith Schober, Sabine Steiner, Andrea Willfort-Ehringer] Geschlecht, metabolische Kontrolle und Carotis Intima-Media-Dicke bei Kindern und Jugendlichen mit Type 1 Diabetes mellitus Summary: Background: Despite a marked improvement in the overall prognosis of patients with type 1 diabetes mellitus (T1DM), cardiovascular morbidity/mortality is still increased. Since cellular and microvascular aberrations have been demonstrated already in children with T1DM, albeit a good glycemic control (CO), we hypothesized that early macrovascular changes can be detected by common carotid artery intima-media thickness (CCA-IMT). Methods: We included 73 children/adolescents with T1DM (34 boys, 39 girls; mean age, 14.8±2 years) and 243 sex- and age-matched healthy CO. In T1DM mean HbA1c was 7.9±1.1 rel.%, and duration of disease 7.5±3.1 years. High-resolution ultrasonography was used to assess CCA-IMT, defined as the mean of 24 measurements of the near and far wall on both right and left CCA. Results: CCA-IMT was not different in the total of children and adolescents with T1DM compared with CO (0.302±0.057 vs. 0.301±0.054mm; p=0.88). Analysis according to gender, however, revealed higher CCA-IMT values in girls than in boys in the diabetic cohort (0.315±0.055 vs. 0.288±0.058mm; p=0.047), whereas CCA-IMT was higher in boys than in girls in the CO group (0.321±0.057 vs. 0.284±0.045mm; p<0.001). Multiple stepwise backward regression showed that in the T1DM group only HbA1c remained significantly associated with CCA-IMT (Beta=−0.307, p=0.008). In CO, gender (Beta=−0.302, p<0.001), body mass index (Beta=0.226, p<0.001) and systolic blood pressure (Beta=0.213, p<0.001) were predictive of CCA-IMT. Conclusion: Our data suggest that in children/adolescents with T1DM the quality of metabolic CO (HbA1c) is the most important predictor of CCA-IMT and outweighs the effect of gender. Springer-Verlag Wien, 2014 Children nationallicence Type 1 diabetes mellitus nationallicence Intima-media-thickness nationallicence Macrovascular nationallicence Ultrasound nationallicence Kinder nationallicence Typ 1 Diabetes Mellitus nationallicence Intima-Media-Dicke nationallicence Makrovaskulär nationallicence Ultraschall nationallicence Giurgea Georgiana-Aura Department of Medicine II, Division of Angiology, Medical University & General Hospital Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria aut Nagl Katrin Pediatrics and Adolescent Medicine, Medical University & General Hospital Vienna, Vienna, Austria aut Gschwandtner Michael Department of Medicine II, Division of Angiology, Medical University & General Hospital Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria aut Höbaus Clemens Department of Medicine II, Division of Angiology, Medical University & General Hospital Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria aut Hörtenhuber Thomas Pediatrics and Adolescent Medicine, Medical University & General Hospital Vienna, Vienna, Austria aut Koppensteiner Renate Department of Medicine II, Division of Angiology, Medical University & General Hospital Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria aut Margeta Christian Department of Medicine II, Division of Angiology, Medical University & General Hospital Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria aut Fritsch Maria Pediatrics and Adolescent Medicine, Medical University & General Hospital Vienna, Vienna, Austria aut Rami-Merhar Birgit Pediatrics and Adolescent Medicine, Medical University & General Hospital Vienna, Vienna, Austria aut Schernthaner Gerit-Holger Department of Medicine II, Division of Angiology, Medical University & General Hospital Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria aut Schlager Oliver Department of Medicine II, Division of Angiology, Medical University & General Hospital Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria aut Schober Edith Pediatrics and Adolescent Medicine, Medical University & General Hospital Vienna, Vienna, Austria aut Steiner Sabine Department of Medicine II, Division of Angiology, Medical University & General Hospital Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria aut Willfort-Ehringer Andrea Department of Medicine II, Division of Angiology, Medical University & General Hospital Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria aut Wiener klinische Wochenschrift Springer Vienna 127/3-4(2015-02-01), 116-123 0043-5325 127:3-4<116 2015 127 508 https://doi.org/10.1007/s00508-014-0640-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00508-014-0640-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Giurgea Georgiana-Aura Department of Medicine II, Division of Angiology, Medical University & General Hospital Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria aut NATIONALLICENCE 700 1- Nagl Katrin Pediatrics and Adolescent Medicine, Medical University & General Hospital Vienna, Vienna, Austria aut NATIONALLICENCE 700 1- Gschwandtner Michael Department of Medicine II, Division of Angiology, Medical University & General Hospital Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria aut NATIONALLICENCE 700 1- Höbaus Clemens Department of Medicine II, Division of Angiology, Medical University & General Hospital Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria aut NATIONALLICENCE 700 1- Hörtenhuber Thomas Pediatrics and Adolescent Medicine, Medical University & General Hospital Vienna, Vienna, Austria aut NATIONALLICENCE 700 1- Koppensteiner Renate Department of Medicine II, Division of Angiology, Medical University & General Hospital Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria aut NATIONALLICENCE 700 1- Margeta Christian Department of Medicine II, Division of Angiology, Medical University & General Hospital Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria aut NATIONALLICENCE 700 1- Fritsch Maria Pediatrics and Adolescent Medicine, Medical University & General Hospital Vienna, Vienna, Austria aut NATIONALLICENCE 700 1- Rami-Merhar Birgit Pediatrics and Adolescent Medicine, Medical University & General Hospital Vienna, Vienna, Austria aut NATIONALLICENCE 700 1- Schernthaner Gerit-Holger Department of Medicine II, Division of Angiology, Medical University & General Hospital Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria aut NATIONALLICENCE 700 1- Schlager Oliver Department of Medicine II, Division of Angiology, Medical University & General Hospital Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria aut NATIONALLICENCE 700 1- Schober Edith Pediatrics and Adolescent Medicine, Medical University & General Hospital Vienna, Vienna, Austria aut NATIONALLICENCE 700 1- Steiner Sabine Department of Medicine II, Division of Angiology, Medical University & General Hospital Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria aut NATIONALLICENCE 700 1- Willfort-Ehringer Andrea Department of Medicine II, Division of Angiology, Medical University & General Hospital Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria aut NATIONALLICENCE 773 0- Wiener klinische Wochenschrift Springer Vienna 127/3-4(2015-02-01), 116-123 0043-5325 127:3-4<116 2015 127 508