caa a22 4500 606239693 CHVBK 20210128101304.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00508-014-0635-0 doi (NATIONALLICENCE)springer-10.1007/s00508-014-0635-0 The Radio-protective effects of Caffeic Acid Phenethyl Ester and Thymoquinone in rats exposed to total head irradiation [Elektronische Daten] [Oztekin Cikman, Seyithan Taysi, Murat Taner Gulsen, Elif Demir, Muslum Akan, Halit Diril, Hasan Ali Kiraz, Muammer Karaayvaz, Mehmet Tarakcioglu] Radioprotektive Wirkung von Kaffeesäurephenylethylester und Thymoquinon gegen oxidativen Stress im Lebergewebe von Ratten nach Exposition einer Gesamtschädelbestrahlung Summary: Background: Many cancer patients treated with radiotherapy suffer severe side effects during and after their treatment. The aim of this study was to investigate the effects of irradiation and the addition of caffeic acid phenethyl ester (CAPE) and thymoquinone (TQ) on the oxidant/antioxidant system in the liver tissue of irradiated rats. Methods: A total of 40 Sprague-Dawley rats were divided into five groups to test the radioprotective effectiveness of thymoquinone and caffeic acid phenethyl ester administered by intraperitoneal injection. Appropriate control groups were also studied. Results: While liver tissue total oxidant status, lipid hydroperoxide level, and oxidative stress index were significantly increased in the irradiated (IR) group, compared with other groups, total antioxidant status, sulfhydryl levels, and paraoxonase (PON) activity were significantly decreased. Ceruloplasmin activity in IR plus TQ and IR groups was higher than the control group. Arylesterase and PON activities in IR plus TQ- and IR plus CAPE-supplemented groups were lower than those of control groups. Conclusions: TQ and CAPE decrease oxidative stress markers and have antioxidant effects, which also augment antioxidant capacity in the liver tissue of irradiated rats. Springer-Verlag Wien, 2014 Caffeic acid phenethyl ester nationallicence Thymoquinone nationallicence Irradiation nationallicence Free radicals nationallicence Total oxidant status nationallicence Total antioxidant status nationallicence Oxidative stress index nationallicence Kaffeesäurephenylethylester nationallicence Thymoquinon nationallicence Bestrahlung nationallicence Freie Radikale nationallicence Gesamt oxidativer Status nationallicence Gesamt antioxidativer Status nationallicence Oxidativer Stress Index nationallicence Cikman Oztekin Department of General Surgery, Faculty of Medicine, Canakkale 18 March University, Canakkale, Turkey aut Taysi Seyithan Department of Medical Biochemistry, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey aut Gulsen Murat Taner Department of Gastroenterology, Faculty of Medicine,Gaziantep University, Gaziantep, Turkey aut Demir Elif Department of Medical Biochemistry, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey aut Akan Muslum Department of Medical Biochemistry, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey aut Diril Halit Department of Medical Biochemistry, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey aut Kiraz Hasan Ali Department of Anesthesiology, Faculty of Medicine, Canakkale 18 March University, Canakkale, Turkey aut Karaayvaz Muammer Department of General Surgery, Faculty of Medicine, Canakkale 18 March University, Canakkale, Turkey aut Tarakcioglu Mehmet Department of Medical Biochemistry, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey aut Wiener klinische Wochenschrift Springer Vienna 127/3-4(2015-02-01), 103-108 0043-5325 127:3-4<103 2015 127 508 https://doi.org/10.1007/s00508-014-0635-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00508-014-0635-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cikman Oztekin Department of General Surgery, Faculty of Medicine, Canakkale 18 March University, Canakkale, Turkey aut NATIONALLICENCE 700 1- Taysi Seyithan Department of Medical Biochemistry, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey aut NATIONALLICENCE 700 1- Gulsen Murat Taner Department of Gastroenterology, Faculty of Medicine,Gaziantep University, Gaziantep, Turkey aut NATIONALLICENCE 700 1- Demir Elif Department of Medical Biochemistry, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey aut NATIONALLICENCE 700 1- Akan Muslum Department of Medical Biochemistry, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey aut NATIONALLICENCE 700 1- Diril Halit Department of Medical Biochemistry, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey aut NATIONALLICENCE 700 1- Kiraz Hasan Ali Department of Anesthesiology, Faculty of Medicine, Canakkale 18 March University, Canakkale, Turkey aut NATIONALLICENCE 700 1- Karaayvaz Muammer Department of General Surgery, Faculty of Medicine, Canakkale 18 March University, Canakkale, Turkey aut NATIONALLICENCE 700 1- Tarakcioglu Mehmet Department of Medical Biochemistry, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey aut NATIONALLICENCE 773 0- Wiener klinische Wochenschrift Springer Vienna 127/3-4(2015-02-01), 103-108 0043-5325 127:3-4<103 2015 127 508