caa a22 4500 60623988X CHVBK 20210128101305.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00508-014-0683-5 doi (NATIONALLICENCE)springer-10.1007/s00508-014-0683-5 Does neutrophil-to-lymphocyte ratio predict active ulcerative colitis? [Elektronische Daten] [Emrah Posul, Bulent Yilmaz, Gulali Aktas, Mevlut Kurt] Sagt der Neutrophilen/Lymphozyten Quotient die Aktivität einer Colitis ulcerosa voraus? Summary: Background: Inflammatory markers have been studied in ulcerative colitis (UC) for diagnosis, disease activity, and prediction of relapse. Blood neutrophil-to-lymphocyte (N/L) ratio has been used to determine outcomes of some malignancies and coronary artery disease. Blood N/L ratio is a simple sign of clinical inflammation. In this study, we examined N/L ratio in recurrent patients suffering from UC. Methods: The aim of the present study was to analyze N/L ratios in serum samples of UC patients in remission and active phases. Patients' age, extend of the disease, disease duration, disease activity, drug, and other medical history were all noted for patients. C-reactive protein, erythrocyte sedimentation rate, and complete blood count were determined for patients. Results: Forty-nine UC patients were admitted into the present study. The blood N/L ratios were significantly increased in active phase compared with inactive UC patients (p<0.05). The cut-off value for N/L ratio for the detection of active UC patients was calculated as ≥2.3 using receiver operating characteristic analysis [sensitivity: 61.2%, specificity: 66.7%, AUC: 0.650 (0.540-0.760), p=0.01]. Conclusions: Present study shows that in patients with UC, the blood N/L ratio is associated with active disease. N/L ratio may be used as an activity parameter in UC. Springer-Verlag Wien, 2014 Neutrophil-to-lymphocyte ratio nationallicence Severity nationallicence Recurrence nationallicence Ulcerative colitis nationallicence Neutrophile/Lymphozyten Quotient nationallicence Schweregrad nationallicence Rezidiv nationallicence Colitis ulcerosa nationallicence Posul Emrah Faculty of Medicine, Department of Gastroenterology, Abant Izzet Baysal University, Golkoy, 14280, Bolu, Turkey aut Yilmaz Bulent Department of Gastroenterology, Bolu Izzet Baysal State Hospital, Bolu, Turkey aut Aktas Gulali Faculty of Medicine, Internal Medicine, Abant Izzet Baysal University, Bolu, Turkey aut Kurt Mevlut Faculty of Medicine, Department of Gastroenterology, Abant Izzet Baysal University, Golkoy, 14280, Bolu, Turkey aut Wiener klinische Wochenschrift Springer Vienna 127/7-8(2015-04-01), 262-265 0043-5325 127:7-8<262 2015 127 508 https://doi.org/10.1007/s00508-014-0683-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00508-014-0683-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Posul Emrah Faculty of Medicine, Department of Gastroenterology, Abant Izzet Baysal University, Golkoy, 14280, Bolu, Turkey aut NATIONALLICENCE 700 1- Yilmaz Bulent Department of Gastroenterology, Bolu Izzet Baysal State Hospital, Bolu, Turkey aut NATIONALLICENCE 700 1- Aktas Gulali Faculty of Medicine, Internal Medicine, Abant Izzet Baysal University, Bolu, Turkey aut NATIONALLICENCE 700 1- Kurt Mevlut Faculty of Medicine, Department of Gastroenterology, Abant Izzet Baysal University, Golkoy, 14280, Bolu, Turkey aut NATIONALLICENCE 773 0- Wiener klinische Wochenschrift Springer Vienna 127/7-8(2015-04-01), 262-265 0043-5325 127:7-8<262 2015 127 508