caa a22 4500 606239944 CHVBK 20210128101305.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00508-015-0719-5 doi (NATIONALLICENCE)springer-10.1007/s00508-015-0719-5 Diagnostic and prognostic value of sCD14-ST—presepsin for patients admitted to hospital intensive care unit (ICU) [Elektronische Daten] [Matej Godnic, David Stubjar, Miha Skvarc, Tomislav Jukic] Background: Sepsis is a serious problem in intensive care units all over the world. Biomarkers could be useful to identify patients at risk. We focused especially on the performance of presepsin (sCD14-ST), compared to C-reactive protein (CRP), procalcitonin (PCT) and CD64, to determine its diagnostic and prognostic indications. Methods: The study was conducted on 47 hospitalized patients after procedures, who were divided into three groups; systemic inflammatory response (SIRS), sepsis and septic shock. Expression of CD64 on neutrophils presented as CD64 index, sCD14-ST, CRP and PCT were measured in whole blood or plasma samples. All patients had standard samples like urine, respiratory tract samples etc. taken for culturing. Blood cultures were drawn to confirm bloodstream infection. Results: Forty (85 %) patients had SIRS with bacterial infection and seven (15 %) patients had SIRS with no infection. All infections were confirmed with blood cultures. Biomarkers were evaluated in all patients. In patients with confirmed infection the values were high. The patients with bacterial infection showed statistical significance with CD64 index (p = 0.003), CRP (p = 0.049) and sCD14-ST (p = 0.026), but not with PCT (p = 1.000). The severity of diagnosed SIRS was significant only with PCT (p < 0.001). Conclusion: CD64 index, CRP and sCD14-ST served as good parameters to determine possible infection in patients that needed intensive care after major procedures. Values of PCT were the only ones to predict SIRS severity and could distinguish between sepsis and severe sepsis or septic shock. Springer-Verlag Wien, 2015 Inflammatory biomarkers nationallicence Infection nationallicence SCD14-ST nationallicence CD64 nationallicence CRP nationallicence PCT nationallicence Sepsis recognition nationallicence Godnic Matej Novo mesto General Hospital, Novo mesto, Slovenia aut Stubjar David Faculty of Medicine, Institute of Microbiology and Immunology, University of Ljubljana, Zaloska 4, Ljubljana, Slovenia aut Skvarc Miha Faculty of Medicine, Institute of Microbiology and Immunology, University of Ljubljana, Zaloska 4, Ljubljana, Slovenia aut Jukic Tomislav Medical faculty of Osijek, Osijek, Croatia aut Wiener klinische Wochenschrift Springer Vienna 127/13-14(2015-07-01), 521-527 0043-5325 127:13-14<521 2015 127 508 https://doi.org/10.1007/s00508-015-0719-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00508-015-0719-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Godnic Matej Novo mesto General Hospital, Novo mesto, Slovenia aut NATIONALLICENCE 700 1- Stubjar David Faculty of Medicine, Institute of Microbiology and Immunology, University of Ljubljana, Zaloska 4, Ljubljana, Slovenia aut NATIONALLICENCE 700 1- Skvarc Miha Faculty of Medicine, Institute of Microbiology and Immunology, University of Ljubljana, Zaloska 4, Ljubljana, Slovenia aut NATIONALLICENCE 700 1- Jukic Tomislav Medical faculty of Osijek, Osijek, Croatia aut NATIONALLICENCE 773 0- Wiener klinische Wochenschrift Springer Vienna 127/13-14(2015-07-01), 521-527 0043-5325 127:13-14<521 2015 127 508