caa a22 4500 606240098 CHVBK 20210128101306.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00508-015-0854-z doi (NATIONALLICENCE)springer-10.1007/s00508-015-0854-z Impaired coronary blood flow may be related to elevated homocysteine levels in patients with metabolic syndrome [Elektronische Daten] [Yusuf I. Alihanoglu, Bekir S. Yildiz, Emin E. Özcan, Dogu I. Kilic, Deniz S. Kuru, Ozgur Taskoylu, Halil Tanriverdi, Havane A. Kaftan, Harun Evrengul] Summary: Background: Metabolic syndrome (MS) refers to a group of cardiovascular risk factors associated with endothelial dysfunction and impaired coronary blood flow (CBF). Homocysteine (Hcy) is another risk factor for the development of insulin resistance and endothelial dysfunction. However, the relationship between Hcy levels and CBF in patients with MS has not been investigated specifically. In the present study, we aimed to evaluate the relationship between Hcy levels and CBF in MS patients with normal coronary arteries. Methods: The study population included 36 patients with MS (20 males, 16 females; mean age = 55 ± 9 years) and 36 control subjects (20 males, 16 females; mean age = 51 ± 7 years). All subjects had angiographically proven normal coronary arteries. Plasma Hcy concentrations were evaluated after a fast of 12h or longer. The CBF rates of all subjects were documented by the thrombolysis in myocardial infarction (TIMI) frame count method. Results: The TIMI frame counts for each major epicardial coronary artery and mean TIMI frame count were found to be significantly higher in the MS group compared with the control group (left anterior descending coronary artery (LAD): 53 ± 26 vs. 39 ± 17; p = 0.01, left circumflex artery (LCx): 32 ± 12 vs. 26 ± 11; p = 0.01, right coronary artery (RCA): 33 ± 14 vs. 26 ± 12; p = 0.02, mean TIMI frame count: 39 ± 16 vs. 20 ± 12; p = 0.01). Plasma Hcy levels in patients with MS were significantly higher compared with controls (MS group = 11.6 ± 4 and control group = 9.6 ± 2.6; p = 0.01). Additionally, plasma Hcy levels were positively correlated with each calculated TIMI frame count value in the MS group (LAD, r: 0.28 and p = 0.006; LCx, r: 0.25 and p = 0.022; RCA, r: 0.26 and p = 0.042; mean TIMI frame count, r: 0.28 and p = 0.004). Conclusion: Plasma Hcy levels and TIMI frame counts were significantly higher in patients with MS. Impaired CBF in MS may be related to elevated levels of Hcy, even if Hcy levels are normal. Springer-Verlag Wien, 2015 Metabolic syndrome nationallicence Homocysteine nationallicence Coronary flow rate nationallicence TIMI frame count nationallicence Alihanoglu Yusuf I. Medical Faculty, Department of Cardiology, Pamukkale University, Denizli, Turkey aut Yildiz Bekir S. Medical Faculty, Department of Cardiology, Pamukkale University, Denizli, Turkey aut Özcan Emin E. Medical Faculty, Department of Cardiology, Sifa University, Denizli, Turkey aut Kilic Dogu I. Medical Faculty, Department of Cardiology, Pamukkale University, Denizli, Turkey aut Kuru Deniz S. Department of Cardiology, Referans Private Hospital, Aydın, Turkey aut Taskoylu Ozgur Department of Cardiology, ERPA Private Hospital, Denizli, Turkey aut Tanriverdi Halil Medical Faculty, Department of Cardiology, Pamukkale University, Denizli, Turkey aut Kaftan Havane A. Medical Faculty, Department of Cardiology, Pamukkale University, Denizli, Turkey aut Evrengul Harun Medical Faculty, Department of Cardiology, Pamukkale University, Denizli, Turkey aut Wiener klinische Wochenschrift Springer Vienna 127/21-22(2015-11-01), 864-870 0043-5325 127:21-22<864 2015 127 508 https://doi.org/10.1007/s00508-015-0854-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00508-015-0854-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Alihanoglu Yusuf I. Medical Faculty, Department of Cardiology, Pamukkale University, Denizli, Turkey aut NATIONALLICENCE 700 1- Yildiz Bekir S. Medical Faculty, Department of Cardiology, Pamukkale University, Denizli, Turkey aut NATIONALLICENCE 700 1- Özcan Emin E. Medical Faculty, Department of Cardiology, Sifa University, Denizli, Turkey aut NATIONALLICENCE 700 1- Kilic Dogu I. Medical Faculty, Department of Cardiology, Pamukkale University, Denizli, Turkey aut NATIONALLICENCE 700 1- Kuru Deniz S. Department of Cardiology, Referans Private Hospital, Aydın, Turkey aut NATIONALLICENCE 700 1- Taskoylu Ozgur Department of Cardiology, ERPA Private Hospital, Denizli, Turkey aut NATIONALLICENCE 700 1- Tanriverdi Halil Medical Faculty, Department of Cardiology, Pamukkale University, Denizli, Turkey aut NATIONALLICENCE 700 1- Kaftan Havane A. Medical Faculty, Department of Cardiology, Pamukkale University, Denizli, Turkey aut NATIONALLICENCE 700 1- Evrengul Harun Medical Faculty, Department of Cardiology, Pamukkale University, Denizli, Turkey aut NATIONALLICENCE 773 0- Wiener klinische Wochenschrift Springer Vienna 127/21-22(2015-11-01), 864-870 0043-5325 127:21-22<864 2015 127 508