caa a22 4500 606240128 CHVBK 20210128101306.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00508-015-0710-1 doi (NATIONALLICENCE)springer-10.1007/s00508-015-0710-1 Yuan Shi-Min Department of Cardiothoracic Surgery, The First Hospital of Putian, Teaching Hospital, Fujian Medical University, 389 Longdejing Street, Chengxiang District, 351100, Putian, Fujian Province, People's Republic of China aut Acquired left ventricle-to-right atrium shunt: clinical implications and diagnostic dilemmas [Elektronische Daten] [Shi-Min Yuan] Summary: Background: The acquired left ventricle-to-right atrium (LV-RA) shunt (Gerbode defect) is rare but it can sometimes be a critical condition. The diagnosis is quite challenging largely due to its exotic anatomic features and diagnostic difficulties. This study aims to present the clinical features and diagnostic solutions of this rare lesion. Methods: Data source was based on a comprehensive literature retrieval of acquired LV-RA shunts of 1990-2014. Results: Most of the acquired LV-RA shunts are of either a postoperative or an infective etiology. Transthoracic echocardiography showed a 62.2% accurate diagnosis, 13.4% inclusive diagnosis, 9.8% missed diagnosis, and 14.5% misdiagnosis rate. The accurate diagnostic rate of transthoracic echocardiography was significantly lower than that of the transesophageal echocardiography or cardiac catheterization. The LV-RA shunts are often misinterpreted as mitral regurgitation, pulmonary hypertension, tricuspid regurgitation, Valsalva aneurysm rupture, and subaortic/high perimembrane/residual ventricular septal defect. Surgical, interventional, and conservative treatments were applied in 57.8, 24.4, and 17.8% patients, respectively. Prognosis showed an event-free survival of 85%, a comorbidity of 9.1%, and a mortality of 13.6%. Conclusions: A high jet detected in the right atrium with uncertain origin and course has to appeal to additional diagnostic techniques including transesophageal echocardiography, cardiac catheterization, or cardiac magnetic resonance imaging for differential diagnoses. Small restrictive shunts are preferred with conservative treatments, high-risk patients are candidates of interventional therapy, and the patients with unstable hemodynamics warrant an open heart surgery. Careful operative maneuver, good control of intracardiac infection, preservation of heart function, etc., are mandatory for the prevention of the development of an acquired LV-RA shunt. Springer-Verlag Wien, 2015 Congenital heart defects nationallicence Endocarditis nationallicence Septal occluder device nationallicence Wiener klinische Wochenschrift Springer Vienna 127/21-22(2015-11-01), 884-892 0043-5325 127:21-22<884 2015 127 508 https://doi.org/10.1007/s00508-015-0710-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00508-015-0710-1 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Yuan Shi-Min Department of Cardiothoracic Surgery, The First Hospital of Putian, Teaching Hospital, Fujian Medical University, 389 Longdejing Street, Chengxiang District, 351100, Putian, Fujian Province, People's Republic of China aut NATIONALLICENCE 773 0- Wiener klinische Wochenschrift Springer Vienna 127/21-22(2015-11-01), 884-892 0043-5325 127:21-22<884 2015 127 508