caa a22 4500 606240179 CHVBK 20210128101307.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00508-015-0868-6 doi (NATIONALLICENCE)springer-10.1007/s00508-015-0868-6 Prognostic significance of transaminases after acute ST-elevation myocardial infarction: insights from a cardiac magnetic resonance study [Elektronische Daten] [Sebastian J. Reinstadler, Martin Reindl, Hans-Josef Feistritzer, Gert Klug, Agnes Mayr, Markus Kofler, Alexander Minh-Duc Tu, Luc Huybrechts, Johannes Mair, Wolfgang-Michael Franz, Bernhard Metzler] Summary: Background: In patients with ST-elevation myocardial infarction (STEMI), the relationship between transaminases and myocardial damage detected by cardiac magnetic resonance (CMR) imaging is unknown and the prognostic value incompletely investigated. Materials and methods: CMR imaging was performed in 167 STEMI patients 2.3 [1.6-3.9] days after primary percutaneous coronary intervention (PPCI). Blood samples for transaminase measurement (aspartate transaminase (AST) and alanine transaminase (ALT)) were obtained serially from day 1 to day 4 after PPCI. Patients were followed for major adverse cardiac events (MACE) for 2.7 [1.1-3.3] years. Results: Admission and peak concentrations of AST and ALT were significantly associated with ejection fraction (p < 0.001), infarct size (p < 0.001), and the presence of microvascular obstruction (p < 0.01). Peak values of both transaminases showed a stronger correlation with CMR parameters than admission values (all p < 0.05). In Kaplan-Meier analysis, a high peak AST or high peak ALT was associated with reduced MACE-free survival (both p < 0.01), whereas admission values were not (both p > 0.05). Peak AST (hazard ratio (HR): 4.93 [1.70-14.32], p = 0.003) and peak ALT (HR: 5.67 [1.94-16.56], p = 0.002) were independent predictors of MACE after adjusting for clinical risk factors. Conclusions: Transaminases measured in the acute phase after PPCI for STEMI are associated with systolic dysfunction, more extensive myocardial necrosis and microvascular injury with subsequent prognostic information on MACE at long-term follow-up. Springer-Verlag Wien, 2015 Transaminases nationallicence Myocardial infarction nationallicence Cardiac magnetic resonance nationallicence Prognosis nationallicence Major adverse cardiac events nationallicence Reinstadler Sebastian J. University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria aut Reindl Martin University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria aut Feistritzer Hans-Josef University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria aut Klug Gert University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria aut Mayr Agnes Department of Radiology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria aut Kofler Markus Department of Cardiac Surgery, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria aut Tu Alexander Minh-Duc University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria aut Huybrechts Luc University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria aut Mair Johannes University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria aut Franz Wolfgang-Michael University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria aut Metzler Bernhard University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria aut Wiener klinische Wochenschrift Springer Vienna 127/21-22(2015-11-01), 843-850 0043-5325 127:21-22<843 2015 127 508 https://doi.org/10.1007/s00508-015-0868-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00508-015-0868-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Reinstadler Sebastian J. University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria aut NATIONALLICENCE 700 1- Reindl Martin University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria aut NATIONALLICENCE 700 1- Feistritzer Hans-Josef University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria aut NATIONALLICENCE 700 1- Klug Gert University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria aut NATIONALLICENCE 700 1- Mayr Agnes Department of Radiology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria aut NATIONALLICENCE 700 1- Kofler Markus Department of Cardiac Surgery, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria aut NATIONALLICENCE 700 1- Tu Alexander Minh-Duc University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria aut NATIONALLICENCE 700 1- Huybrechts Luc University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria aut NATIONALLICENCE 700 1- Mair Johannes University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria aut NATIONALLICENCE 700 1- Franz Wolfgang-Michael University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria aut NATIONALLICENCE 700 1- Metzler Bernhard University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria aut NATIONALLICENCE 773 0- Wiener klinische Wochenschrift Springer Vienna 127/21-22(2015-11-01), 843-850 0043-5325 127:21-22<843 2015 127 508