caa a22 4500 606240217 CHVBK 20210128101307.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s00508-015-0880-x doi (NATIONALLICENCE)springer-10.1007/s00508-015-0880-x Clinical Practice Guideline for the prevention and early detection of breast and ovarian cancer in women from HBOC (hereditary breast and ovarian cancer) families [Elektronische Daten] [C.F. Singer, M.K. Tea, G. Pristauz, M. Hubalek, C. Rappaport, C.C. Riedl, T.H. Helbich] Summary: An estimated 10 % of breast cancer cases exhibit a higher familial incidence, and functional mutations in BRCA (breast cancer-gene) 1 or 2 are responsible for the development of malignant tumors in approximately half of these cases. Women with a germline mutation in either of the two genes have a lifetime risk of up to 85 % to develop breast cancer, and of up to 60 % risk to develop ovarian cancer. This clinical practice guideline defines the individual and familial tumor constellations that represent an indication for BRCA germline testing. It also describes the therapeutic options (early detection programme vs prophylactic surgery) that arise from the result of a BRCA mutational analysis. This guideline further includes recommendations regarding the use of multigene panels and therapeutic aspects that arise from the selective use of poly ADP ribose polymerase (PARP) inhibitors in patients with known BRCA1 or 2 mutations. It replaces the previous version of the "Clinical Practice Guideline for the Prevention and Early Detection of Breast- and Ovarian Cancer in women from HBOC (hereditary breast and ovarian cancer) families” which was published in 2012. Springer-Verlag Wien, 2015 BRCA nationallicence Hereditary Breast and Ovarian Cancer nationallicence PBSO nationallicence PBM nationallicence Singer C.F. Gynecological Oncology, Medical University of Vienna, Department of Gynaecology, Comprehensive Cancer Center, Waehringer Guertel 18-20, 1090, Vienna, Austria aut Tea M.K. Gynecological Oncology, Medical University of Vienna, Department of Gynaecology, Comprehensive Cancer Center, Waehringer Guertel 18-20, 1090, Vienna, Austria aut Pristauz G. Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria aut Hubalek M. Department of Obstetrics and Gynecology, Medical University of Innsbruck, Innsbruck, Austria aut Rappaport C. Gynecological Oncology, Medical University of Vienna, Department of Gynaecology, Comprehensive Cancer Center, Waehringer Guertel 18-20, 1090, Vienna, Austria aut Riedl C.C. Department of Radiology, Medical University of Vienna, Vienna, Austria aut Helbich T.H. Department of Radiology, Medical University of Vienna, Vienna, Austria aut Wiener klinische Wochenschrift Springer Vienna 127/23-24(2015-12-01), 981-986 0043-5325 127:23-24<981 2015 127 508 https://doi.org/10.1007/s00508-015-0880-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00508-015-0880-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Singer C.F. Gynecological Oncology, Medical University of Vienna, Department of Gynaecology, Comprehensive Cancer Center, Waehringer Guertel 18-20, 1090, Vienna, Austria aut NATIONALLICENCE 700 1- Tea M.K. Gynecological Oncology, Medical University of Vienna, Department of Gynaecology, Comprehensive Cancer Center, Waehringer Guertel 18-20, 1090, Vienna, Austria aut NATIONALLICENCE 700 1- Pristauz G. Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria aut NATIONALLICENCE 700 1- Hubalek M. Department of Obstetrics and Gynecology, Medical University of Innsbruck, Innsbruck, Austria aut NATIONALLICENCE 700 1- Rappaport C. Gynecological Oncology, Medical University of Vienna, Department of Gynaecology, Comprehensive Cancer Center, Waehringer Guertel 18-20, 1090, Vienna, Austria aut NATIONALLICENCE 700 1- Riedl C.C. Department of Radiology, Medical University of Vienna, Vienna, Austria aut NATIONALLICENCE 700 1- Helbich T.H. Department of Radiology, Medical University of Vienna, Vienna, Austria aut NATIONALLICENCE 773 0- Wiener klinische Wochenschrift Springer Vienna 127/23-24(2015-12-01), 981-986 0043-5325 127:23-24<981 2015 127 508