caa a22 4500 606240489 CHVBK 20210128101308.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00508-015-0746-2 doi (NATIONALLICENCE)springer-10.1007/s00508-015-0746-2 Association of mean platelet volume level with in-hospital major adverse events in infective endocarditis [Elektronische Daten] [Duran Tok, Uğur Canpolat, Derya Tok, Osman Turak, Ahmet İşleyen, Fatih Öksüz, Mehmet Ali Mendi, Kumral Çağlı, Fatma Nurcan Başar, Zehra Gölbaşı] Summary: We hypothesised that increased on-admission and follow-up mean platelet volume (MPV) levels would correlate with adverse outcomes in patients with infective endocarditis (IE). A total of 108 consecutive patients were grouped into two according to median MPV level (≤ 8.6 and > 8.6fL). Patients with MPV level of > 8.6fL had a significantly higher rate of end-stage renal disease, Staphylococcus aureus infection, higher CRP levels, embolic events and in-hospital mortality compared to patients with MPV levels ≤ 8.6fL. In multivariable Cox regression analysis, previous history of IE, S. aureus infection, end-stage renal disease, depressed LVEF, early surgical intervention, vegetation size ≥ 10mm, presence of perivalvular abscess, higher on-admission platelet count, CRP and MPV levels emerged as independent predictors of in-hospital unfavourable outcomes. Patients with embolic events and in-hospital mortality revealed an incremental trend for MPV levels compared to patients without any adverse events. Our study results suggest that both on-admission and follow-up MPV levels may be a simple and available biomarker for risk stratification of IE patients. Springer-Verlag Wien, 2015 Infective endocarditis nationallicence In-hospital mortality nationallicence Embolism nationallicence Mean platelet volume nationallicence Tok Duran Department of Infectious Diseases, Turkish Armed Forces Health Command Health and Veterinary Services, Ankara, Turkey aut Canpolat Uğur Cardiology Clinic, Türkiye Yüksek İhtisas Training and Research Hospital, Sıhhiye, 06100, Ankara, Turkey aut Tok Derya Cardiology Clinic, Türkiye Yüksek İhtisas Training and Research Hospital, Sıhhiye, 06100, Ankara, Turkey aut Turak Osman Cardiology Clinic, Türkiye Yüksek İhtisas Training and Research Hospital, Sıhhiye, 06100, Ankara, Turkey aut İşleyen Ahmet Cardiology Clinic, Türkiye Yüksek İhtisas Training and Research Hospital, Sıhhiye, 06100, Ankara, Turkey aut Öksüz Fatih Cardiology Clinic, Türkiye Yüksek İhtisas Training and Research Hospital, Sıhhiye, 06100, Ankara, Turkey aut Mendi Mehmet Ali Cardiology Clinic, Türkiye Yüksek İhtisas Training and Research Hospital, Sıhhiye, 06100, Ankara, Turkey aut Çağlı Kumral Cardiology Clinic, Türkiye Yüksek İhtisas Training and Research Hospital, Sıhhiye, 06100, Ankara, Turkey aut Başar Fatma Nurcan Cardiology Clinic, Türkiye Yüksek İhtisas Training and Research Hospital, Sıhhiye, 06100, Ankara, Turkey aut Gölbaşı Zehra Cardiology Clinic, Türkiye Yüksek İhtisas Training and Research Hospital, Sıhhiye, 06100, Ankara, Turkey aut Wiener klinische Wochenschrift Springer Vienna 127/5-6(2015-03-01), 197-202 0043-5325 127:5-6<197 2015 127 508 https://doi.org/10.1007/s00508-015-0746-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00508-015-0746-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tok Duran Department of Infectious Diseases, Turkish Armed Forces Health Command Health and Veterinary Services, Ankara, Turkey aut NATIONALLICENCE 700 1- Canpolat Uğur Cardiology Clinic, Türkiye Yüksek İhtisas Training and Research Hospital, Sıhhiye, 06100, Ankara, Turkey aut NATIONALLICENCE 700 1- Tok Derya Cardiology Clinic, Türkiye Yüksek İhtisas Training and Research Hospital, Sıhhiye, 06100, Ankara, Turkey aut NATIONALLICENCE 700 1- Turak Osman Cardiology Clinic, Türkiye Yüksek İhtisas Training and Research Hospital, Sıhhiye, 06100, Ankara, Turkey aut NATIONALLICENCE 700 1- İşleyen Ahmet Cardiology Clinic, Türkiye Yüksek İhtisas Training and Research Hospital, Sıhhiye, 06100, Ankara, Turkey aut NATIONALLICENCE 700 1- Öksüz Fatih Cardiology Clinic, Türkiye Yüksek İhtisas Training and Research Hospital, Sıhhiye, 06100, Ankara, Turkey aut NATIONALLICENCE 700 1- Mendi Mehmet Ali Cardiology Clinic, Türkiye Yüksek İhtisas Training and Research Hospital, Sıhhiye, 06100, Ankara, Turkey aut NATIONALLICENCE 700 1- Çağlı Kumral Cardiology Clinic, Türkiye Yüksek İhtisas Training and Research Hospital, Sıhhiye, 06100, Ankara, Turkey aut NATIONALLICENCE 700 1- Başar Fatma Nurcan Cardiology Clinic, Türkiye Yüksek İhtisas Training and Research Hospital, Sıhhiye, 06100, Ankara, Turkey aut NATIONALLICENCE 700 1- Gölbaşı Zehra Cardiology Clinic, Türkiye Yüksek İhtisas Training and Research Hospital, Sıhhiye, 06100, Ankara, Turkey aut NATIONALLICENCE 773 0- Wiener klinische Wochenschrift Springer Vienna 127/5-6(2015-03-01), 197-202 0043-5325 127:5-6<197 2015 127 508