caa a22 4500 606240497 CHVBK 20210128101308.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00508-015-0714-x doi (NATIONALLICENCE)springer-10.1007/s00508-015-0714-x Relation of fragmented QRS to tissue Doppler-derived parametersin patients with familial Mediterranean fever [Elektronische Daten] [Muhammet Murat Celik, Eyup Buyukkaya, Nilgul Ustun, Alper Bugra Nacar, Mustafa Kurt, Mehmet Fatih Karakas, Perihan Bilen, Mehmet Duru, Nihat Sen, Adnan Akcay] Summary: Background: Familial Mediterranean fever (FMF) may pose a risk for cardiovascular diseases due to continuous inflammatory status observed during the course of the disease. Recently, the presence of fragmented QRS (fQRS) has been recognized as a predictor of myocardial fibrosis. In this study, we aim to investigate the frequency of fQRS and its relation to Doppler-based indices. Methods: This study consisted of 80 FMF patients and 30 healthy control subjects. fQRS pattern was defined as the presence of additional R waves or RSR', evidenced by notched R or S wave on electrocardiography (ECG). The patient and the control groups underwent conventional echocardiography and tissue Doppler echocardiography. Results: There was no significant difference between groups regarding age (29 ± 12 vs 29 ± 15). FMF patients exhibited a statistically higher frequency of fQRS (% 56 vs % 13) (p < 0.01). E/Em ratio showed a statistically significant increase in the FMF group with fQRS (p < 0.0001), while the mean Em value was markedly lower (p < 0.0001). Conclusions: FMF patients displayed a statistically significant increase in frequency of fQRS. Doppler-derived diastolic index was statistically significantly impaired in FMF patients with fQRS as compared with the patients without fQRS. In conclusion, fQRS might be a new noninvasive marker for cardiac involvement in FMF patients. Springer-Verlag Wien, 2015 Fragmented QRS nationallicence Familial Mediterranean fever nationallicence Tissue Doppler echocardiography nationallicence Celik Muhammet Murat Faculty of Medicine, Department of Internal Medicine, Mustafa Kemal University, Hatay, Turkey aut Buyukkaya Eyup Faculty of Medicine, Department of Cardiology, Mustafa Kemal University, Hatay, Turkey aut Ustun Nilgul Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Mustafa Kemal University, Hatay, Turkey aut Nacar Alper Bugra Faculty of Medicine, Department of Cardiology, Mustafa Kemal University, Hatay, Turkey aut Kurt Mustafa Faculty of Medicine, Department of Cardiology, Mustafa Kemal University, Hatay, Turkey aut Karakas Mehmet Fatih Faculty of Medicine, Department of Cardiology, Mustafa Kemal University, Hatay, Turkey aut Bilen Perihan Department of Cardiology, Van Training and Research Hospital, Van, Turkey aut Duru Mehmet Faculty of Medicine, Department of Emergency Medicine, Mustafa Kemal University, Hatay, Turkey aut Sen Nihat Faculty of Medicine, Department of Cardiology, Mustafa Kemal University, Hatay, Turkey aut Akcay Adnan Faculty of Medicine, Department of Internal Medicine, Mustafa Kemal University, Hatay, Turkey aut Wiener klinische Wochenschrift Springer Vienna 127/5-6(2015-03-01), 185-190 0043-5325 127:5-6<185 2015 127 508 https://doi.org/10.1007/s00508-015-0714-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00508-015-0714-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Celik Muhammet Murat Faculty of Medicine, Department of Internal Medicine, Mustafa Kemal University, Hatay, Turkey aut NATIONALLICENCE 700 1- Buyukkaya Eyup Faculty of Medicine, Department of Cardiology, Mustafa Kemal University, Hatay, Turkey aut NATIONALLICENCE 700 1- Ustun Nilgul Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Mustafa Kemal University, Hatay, Turkey aut NATIONALLICENCE 700 1- Nacar Alper Bugra Faculty of Medicine, Department of Cardiology, Mustafa Kemal University, Hatay, Turkey aut NATIONALLICENCE 700 1- Kurt Mustafa Faculty of Medicine, Department of Cardiology, Mustafa Kemal University, Hatay, Turkey aut NATIONALLICENCE 700 1- Karakas Mehmet Fatih Faculty of Medicine, Department of Cardiology, Mustafa Kemal University, Hatay, Turkey aut NATIONALLICENCE 700 1- Bilen Perihan Department of Cardiology, Van Training and Research Hospital, Van, Turkey aut NATIONALLICENCE 700 1- Duru Mehmet Faculty of Medicine, Department of Emergency Medicine, Mustafa Kemal University, Hatay, Turkey aut NATIONALLICENCE 700 1- Sen Nihat Faculty of Medicine, Department of Cardiology, Mustafa Kemal University, Hatay, Turkey aut NATIONALLICENCE 700 1- Akcay Adnan Faculty of Medicine, Department of Internal Medicine, Mustafa Kemal University, Hatay, Turkey aut NATIONALLICENCE 773 0- Wiener klinische Wochenschrift Springer Vienna 127/5-6(2015-03-01), 185-190 0043-5325 127:5-6<185 2015 127 508