caa a22 4500 606240667 CHVBK 20210128101309.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00508-014-0614-5 doi (NATIONALLICENCE)springer-10.1007/s00508-014-0614-5 Evaluation of liver perfusion in diabetic patients using 99mTc-sestamibi [Elektronische Daten] [Hacer Şen, Yusuf Ziya Tan, Emine Binnetoğlu, Mehmet Aşik, Fahri Güneş, Gökhan Erbağ, Emine Gazi, Sibel Cevizci, Semra Özdemir, Erdem Akbal, Kubilay Ükinç] Erhebung der Leberperfusion mittels 99mTc-Sestamibi bei Patienten mit Diabetes mellitus Summary: Objective: The liver is an important organ for various aspects of glucose metabolism, including glucose uptake, storage, and synthesis. It is a major organ in the metabolic process with perfusion provided by both the portal vein and hepatic artery. In diabetic patients organ perfusion is reduced and this is linked to atherosclerosis, and as a result complications occur. In this study, we aimed to evaluate liver perfusion by scintigraphic methods in diabetic patients. Design and patients: We retrospectively investigated 1,100 myocardial perfusion scintigraphies taken between January 2011 and December 2012 at Canakkale Onsekiz Mart University Medical Faculty Nuclear Medicine Department. A total of 66 patients who were diagnosed with diabetes mellitus and had myocardial perfusion scintigraphies were included in the study. The control subjects included 127 patients without diabetes mellitus who were chosen at random. Patients with chronic liver disease were not included in the study. The values from liver regions of interest (liver-ROI) rates and heart regions of interest (heart-ROI) rates were compared between the patients and controls. Results: Patients were grouped according to the presence of diabetes. In the diabetes mellitus group, the liver-ROI average was lower (p = 0.66) than in the controls. In the control group, the average liver-ROI/heart-ROI ratios were higher than the ratio in the diabetes mellitus group (p = 0.019). Multivariate variance analysis showed that the diabetes mellitus liver-ROI/heart-ROI ratio was independent of other risk factors (p = 0.003; F: 9.6). Powered by Editorial Manager® and ProduXion Manager® from Aries Systems Corporation. Conclusions: This study shows that liver perfusion in diabetic patients is reduced compared with those without diabetes. Prospective studies with larger patient groups are required. Springer-Verlag Wien, 2014 Diabetes mellitus nationallicence Liver perfusion nationallicence Technetium-99m-2-methoxy-isobutyl-isonitrite nationallicence Liver scintigraphy nationallicence Leberperfusion nationallicence Technetium-99m-2-Methoxyisobutylisonitril nationallicence Leberszintigraphie nationallicence Şen Hacer Department of Internal Medicine, Çanakkale Onsekiz Mart University, Sahil yolu cad., 17100, Çanakkale, Turkey aut Tan Yusuf Ziya Department of Nuclear Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey aut Binnetoğlu Emine Department of Internal Medicine, Çanakkale Onsekiz Mart University, Sahil yolu cad., 17100, Çanakkale, Turkey aut Aşik Mehmet Department of Internal Medicine, Çanakkale Onsekiz Mart University, Sahil yolu cad., 17100, Çanakkale, Turkey aut Güneş Fahri Department of Internal Medicine, Çanakkale Onsekiz Mart University, Sahil yolu cad., 17100, Çanakkale, Turkey aut Erbağ Gökhan Department of Internal Medicine, Çanakkale Onsekiz Mart University, Sahil yolu cad., 17100, Çanakkale, Turkey aut Gazi Emine Department of Cardiology, Çanakkale Onsekiz Mart University, Çanakkale, Turkey aut Cevizci Sibel Department of Public Health, Çanakkale Onsekiz Mart University, Çanakkale, Turkey aut Özdemir Semra Department of Nuclear Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey aut Akbal Erdem Department of Internal Medicine, Çanakkale Onsekiz Mart University, Sahil yolu cad., 17100, Çanakkale, Turkey aut Ükinç Kubilay Department of Internal Medicine, Çanakkale Onsekiz Mart University, Sahil yolu cad., 17100, Çanakkale, Turkey aut Wiener klinische Wochenschrift Springer Vienna 127/1-2(2015-01-01), 19-23 0043-5325 127:1-2<19 2015 127 508 https://doi.org/10.1007/s00508-014-0614-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00508-014-0614-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Şen Hacer Department of Internal Medicine, Çanakkale Onsekiz Mart University, Sahil yolu cad., 17100, Çanakkale, Turkey aut NATIONALLICENCE 700 1- Tan Yusuf Ziya Department of Nuclear Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey aut NATIONALLICENCE 700 1- Binnetoğlu Emine Department of Internal Medicine, Çanakkale Onsekiz Mart University, Sahil yolu cad., 17100, Çanakkale, Turkey aut NATIONALLICENCE 700 1- Aşik Mehmet Department of Internal Medicine, Çanakkale Onsekiz Mart University, Sahil yolu cad., 17100, Çanakkale, Turkey aut NATIONALLICENCE 700 1- Güneş Fahri Department of Internal Medicine, Çanakkale Onsekiz Mart University, Sahil yolu cad., 17100, Çanakkale, Turkey aut NATIONALLICENCE 700 1- Erbağ Gökhan Department of Internal Medicine, Çanakkale Onsekiz Mart University, Sahil yolu cad., 17100, Çanakkale, Turkey aut NATIONALLICENCE 700 1- Gazi Emine Department of Cardiology, Çanakkale Onsekiz Mart University, Çanakkale, Turkey aut NATIONALLICENCE 700 1- Cevizci Sibel Department of Public Health, Çanakkale Onsekiz Mart University, Çanakkale, Turkey aut NATIONALLICENCE 700 1- Özdemir Semra Department of Nuclear Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey aut NATIONALLICENCE 700 1- Akbal Erdem Department of Internal Medicine, Çanakkale Onsekiz Mart University, Sahil yolu cad., 17100, Çanakkale, Turkey aut NATIONALLICENCE 700 1- Ükinç Kubilay Department of Internal Medicine, Çanakkale Onsekiz Mart University, Sahil yolu cad., 17100, Çanakkale, Turkey aut NATIONALLICENCE 773 0- Wiener klinische Wochenschrift Springer Vienna 127/1-2(2015-01-01), 19-23 0043-5325 127:1-2<19 2015 127 508