caa a22 4500 606240748 CHVBK 20210128101309.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00508-014-0630-5 doi (NATIONALLICENCE)springer-10.1007/s00508-014-0630-5 The major predictors of amputation and length of stay in diabetic patients with acute foot ulceration [Elektronische Daten] [Suzan Tabur, Mehmet Ali Eren, Yakup Çelik, Omer Faruk Dağ, Tevfik Sabuncu, Zeynel Abidin Sayiner, Esen Savas] Die wesentlichsten Prädiktoren einer Amputation und der Dauer des Spitalsaufenthaltes bei Diabetikern mit akutem Ulkus im Fußbereich Summary: Background: Diabetic foot infections are associated with substantial morbidity and mortality. Prediction of diabetic foot ulcer outcome may be helpful for optimizing management strategy. This study aimed to determine the major predictors of amputation and length of stay in diabetic patients with acute foot ulceration. Methods: A total of 55 type 2 diabetic patients with diabetic foot infection were enrolled. The patients were evaluated according to the Infectious Diseases Society of America and International Working Group on the Diabetic Foot criteria and also the Wagner's classification. Blood samples were taken at the start of hospitalization for the measurement of glucose, hemoglobin A1C (HbA1C), white blood cells (WBC), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR). Length of stay in hospital was recorded. Results: WBC and CRP were significantly higher in lower-extremity amputation (LEA) group (p=0.001 and p=0.008, respectively); also, ESR was higher in this group, but there was no statistical significance. Wagner grade and infection severity were significantly higher in the LEA group as compared with the non-LEA group (both p values <0.001). Glycemic control parameters (i.e., HbA1C, plasma glucose) were not different in LEA and non-LEA groups. In correlation analyses, amputation rate was negatively correlated (r=−0.512, p<0.001) with length of stay. WBC, ESR, CRP, Wagner grade, and severity of infection showed positive correlation with length of stay (r=0.493, p<0.001; r=0.271, p=0.045; r=0.299, p=0.027; r=0.434, p=0.001; and r=0.464, p<0.001, respectively). Conclusions: Baseline levels of acute-phase reactants, especially CRP, WBC, ESR, and increased Wagner grade, appeared to be helpful in predicting amputation and length of stay in diabetic patients with acute foot ulceration. However, duration of diabetes and glucose control seems to have no effect. Springer-Verlag Wien, 2014 Diabetic foot nationallicence Amputation nationallicence Acute-phase reactants nationallicence Length of stay nationallicence Diabetischer Fuß nationallicence Akutphasenparameter nationallicence Spitalsaufenthaltsdauer nationallicence Tabur Suzan Department of Endocrinology, Gaziantep University Faculty of Medicine, Gaziantep, Turkey aut Eren Mehmet Ali Department of Endocrinology, Balıklıgol State Hospital, Sanliurfa, Turkey aut Çelik Yakup Department of Internal Medicine, Nehır Medical Center, Sanliurfa, Turkey aut Dağ Omer Faruk Department of Internal Medicine, Guney Derman Medical Center, Sanliurfa, Turkey aut Sabuncu Tevfik Department of Endocrinology, Faculty of Medicine, University of Harran, Sanliurfa, Turkey aut Sayiner Zeynel Abidin Department of Internal Medicine, Gaziantep University Faculty of Medicine, Gaziantep, Turkey aut Savas Esen Division of Social Medicine, Department of Internal Medicine, Gaziantep University Faculty of Medicine, Gaziantep, Turkey aut Wiener klinische Wochenschrift Springer Vienna 127/1-2(2015-01-01), 45-50 0043-5325 127:1-2<45 2015 127 508 https://doi.org/10.1007/s00508-014-0630-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00508-014-0630-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tabur Suzan Department of Endocrinology, Gaziantep University Faculty of Medicine, Gaziantep, Turkey aut NATIONALLICENCE 700 1- Eren Mehmet Ali Department of Endocrinology, Balıklıgol State Hospital, Sanliurfa, Turkey aut NATIONALLICENCE 700 1- Çelik Yakup Department of Internal Medicine, Nehır Medical Center, Sanliurfa, Turkey aut NATIONALLICENCE 700 1- Dağ Omer Faruk Department of Internal Medicine, Guney Derman Medical Center, Sanliurfa, Turkey aut NATIONALLICENCE 700 1- Sabuncu Tevfik Department of Endocrinology, Faculty of Medicine, University of Harran, Sanliurfa, Turkey aut NATIONALLICENCE 700 1- Sayiner Zeynel Abidin Department of Internal Medicine, Gaziantep University Faculty of Medicine, Gaziantep, Turkey aut NATIONALLICENCE 700 1- Savas Esen Division of Social Medicine, Department of Internal Medicine, Gaziantep University Faculty of Medicine, Gaziantep, Turkey aut NATIONALLICENCE 773 0- Wiener klinische Wochenschrift Springer Vienna 127/1-2(2015-01-01), 45-50 0043-5325 127:1-2<45 2015 127 508