caa a22 4500 60624087X CHVBK 20210128101310.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00508-015-0720-z doi (NATIONALLICENCE)springer-10.1007/s00508-015-0720-z Serum paraoxonase activity, total thiols levels, and oxidative status in patients with acute brucellosis [Elektronische Daten] [Ramazan Esen, Mehmet Aslan, Mehmet Emin Kucukoglu, Aytekin Cıkman, Umit Yakan, Mahmut Sunnetcioglu, Sahbettin Selek] Summary: It is well known that paraoxonase-1 (PON1) activity may decrease during the course of infection and inflammation. The aim of this study was to investigate serum PON1 activity, oxidative status, and thiols levels in patients with acute brucellosis. In addition, we investigated the PON1 phenotype in patients with acute brucellosis. Thirty patients with acute brucellosis and 35 healthy controls were enrolled. Serum paraoxonase and arylesterase activities, thiols levels, lipid hydroperoxide levels, total antioxidant capacity (TAC), total oxidant status (TOS) and oxidative stress index (OSI) were determined. Serum basal and salt-stimulated paraoxonase-arylesterase activities, TAC levels and thiols levels were significantly lower in patients with acute brucellosis than controls (for all, p<0.05), while LOOH levels, TOS levels, and OSI values were significantly higher (for all, p<0.05). We concluded that oxidative stress is increased, while serum PON1 activity is decreased in patients with acute brucellosis. These results indicate that lower PON1 activity is associated with oxidant-antioxidant imbalance. Springer-Verlag Wien, 2015 Acute brucellosis nationallicence PON1 activity nationallicence Total antioxidant capacity nationallicence Total oxidant status nationallicence Oxidative stress index nationallicence Thiol nationallicence Esen Ramazan Medical Faculty, Department of Internal Medicine, Yuzuncu Yıl University, 65000, Van, Turkey aut Aslan Mehmet Medical Faculty, Department of Internal Medicine, Yuzuncu Yıl University, 65000, Van, Turkey aut Kucukoglu Mehmet Emin Medical Faculty, Department of Internal Medicine, Yuzuncu Yıl University, 65000, Van, Turkey aut Cıkman Aytekin Medical Faculty, Department of Microbiology, Yuzuncu Yıl University, Van, Turkey aut Yakan Umit Medical Faculty, Department of Infectious Disease and Clinical Microbiology, Yuzuncu Yıl University, Van, Turkey aut Sunnetcioglu Mahmut Medical Faculty, Department of Infectious Disease and Clinical Microbiology, Yuzuncu Yıl University, Van, Turkey aut Selek Sahbettin Medical Faculty, Department of Clinical Biochemistry, Bezmialem Vakif University, Istanbul, Turkey aut Wiener klinische Wochenschrift Springer Vienna 127/11-12(2015-06-01), 427-433 0043-5325 127:11-12<427 2015 127 508 https://doi.org/10.1007/s00508-015-0720-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00508-015-0720-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Esen Ramazan Medical Faculty, Department of Internal Medicine, Yuzuncu Yıl University, 65000, Van, Turkey aut NATIONALLICENCE 700 1- Aslan Mehmet Medical Faculty, Department of Internal Medicine, Yuzuncu Yıl University, 65000, Van, Turkey aut NATIONALLICENCE 700 1- Kucukoglu Mehmet Emin Medical Faculty, Department of Internal Medicine, Yuzuncu Yıl University, 65000, Van, Turkey aut NATIONALLICENCE 700 1- Cıkman Aytekin Medical Faculty, Department of Microbiology, Yuzuncu Yıl University, Van, Turkey aut NATIONALLICENCE 700 1- Yakan Umit Medical Faculty, Department of Infectious Disease and Clinical Microbiology, Yuzuncu Yıl University, Van, Turkey aut NATIONALLICENCE 700 1- Sunnetcioglu Mahmut Medical Faculty, Department of Infectious Disease and Clinical Microbiology, Yuzuncu Yıl University, Van, Turkey aut NATIONALLICENCE 700 1- Selek Sahbettin Medical Faculty, Department of Clinical Biochemistry, Bezmialem Vakif University, Istanbul, Turkey aut NATIONALLICENCE 773 0- Wiener klinische Wochenschrift Springer Vienna 127/11-12(2015-06-01), 427-433 0043-5325 127:11-12<427 2015 127 508