caa a22 4500 606240888 CHVBK 20210128101310.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00508-015-0775-x doi (NATIONALLICENCE)springer-10.1007/s00508-015-0775-x Ectopic acromegaly due to a growth hormone-secreting neuroendocrine-differentiated tumor developed from ovarian mature cystic teratoma [Elektronische Daten] [Mesut Ozkaya, Zeynel Abidin Sayiner, Gurkan Kiran, Kamile Gul, Ibrahim Erkutlu, Umut Elboga] Summary: Acromegaly is a clinical syndrome caused by the overproduction of growth hormone (GH) and also known as a rare disease. Clinical, biochemical, and radiological features are often indistinguishable between GH-producing hypophysis adenomas and ectopic GH-releasing hormone (GHRH)-producing tumors. A 40-year-old woman presented to us with her growing feet, hands especially fingers, and enlarging nose. Biochemical diagnosis of acromegaly was made by measuring insulin-like growth factor-1 (IGF-1) level and glucose-suppressed GH estimation. Her spot IGF-1 level was 1300ng/ml (90-226ng/ml). The basal GH was 30ng/l, and 60- and 120-min GH levels after 75-g oral glucose load were 29 and 40ng/l, respectively. Magnetic resonance imaging (MRI) of pituitary was normal. There was no pituitary adenoma or pituitary hyperplasia. Extrapituitary ectopic hypersecretion of GH or GHRH-secreting tumor search was done by high-resolution computed tomography (CT) of chest and whole abdomen. Abdomen CT revealed 9.5 × 8cm pelvic mass, which included calcific regions and solid component. The specimen's immunohistochemical staining with GH was positive but interestingly GHRH was negative. According to immunohistochemical staining, the patient's diagnosis was ectopic acromegaly due to a GH-secreting neuroendocrine-differentiated tumor developed from an ovarian mature cystic teratoma. Herein, we present excellent illustration of an unusual and confusing clinical scenario of ectopic acromegaly. Springer-Verlag Wien, 2015 Acromegaly nationallicence Ectopic acromegaly nationallicence Growth hormone nationallicence Neuroendocrine-differentiated tumor nationallicence Mature cystic teratoma nationallicence Ozkaya Mesut Department of Endocrinology, Gaziantep University Faculty of Medicine, Gaziantep, Turkey aut Sayiner Zeynel Abidin Department of Endocrinology and Metabolism, Gaziantep University Faculty of Medicine, 27100, Sahinbey, Gaziantep, Turkey aut Kiran Gurkan Department of Gynecology and Obstetrics, Sutcu Imam University Faculty of Medicine, Kahramanmaras, Turkey aut Gul Kamile Department of Endocrinology, Sutcu Imam University Faculty of Medicine, Kahramanmaras, Turkey aut Erkutlu Ibrahim Department of Neurosurgery, Gaziantep University Faculty of Medicine, Gaziantep, Turkey aut Elboga Umut Department of Nuclear Medicine, Gaziantep University Faculty of Medicine, Gaziantep, Turkey aut Wiener klinische Wochenschrift Springer Vienna 127/11-12(2015-06-01), 491-493 0043-5325 127:11-12<491 2015 127 508 https://doi.org/10.1007/s00508-015-0775-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 brief-communication jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00508-015-0775-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ozkaya Mesut Department of Endocrinology, Gaziantep University Faculty of Medicine, Gaziantep, Turkey aut NATIONALLICENCE 700 1- Sayiner Zeynel Abidin Department of Endocrinology and Metabolism, Gaziantep University Faculty of Medicine, 27100, Sahinbey, Gaziantep, Turkey aut NATIONALLICENCE 700 1- Kiran Gurkan Department of Gynecology and Obstetrics, Sutcu Imam University Faculty of Medicine, Kahramanmaras, Turkey aut NATIONALLICENCE 700 1- Gul Kamile Department of Endocrinology, Sutcu Imam University Faculty of Medicine, Kahramanmaras, Turkey aut NATIONALLICENCE 700 1- Erkutlu Ibrahim Department of Neurosurgery, Gaziantep University Faculty of Medicine, Gaziantep, Turkey aut NATIONALLICENCE 700 1- Elboga Umut Department of Nuclear Medicine, Gaziantep University Faculty of Medicine, Gaziantep, Turkey aut NATIONALLICENCE 773 0- Wiener klinische Wochenschrift Springer Vienna 127/11-12(2015-06-01), 491-493 0043-5325 127:11-12<491 2015 127 508