caa a22 4500 606240977 CHVBK 20210128101310.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00508-015-0795-6 doi (NATIONALLICENCE)springer-10.1007/s00508-015-0795-6 Monogenic glucokinase diabetes and pregnancy: a case study [Elektronische Daten] [Iva Haladová, Daniela Čechurová, Silvie Lacigová, Zdeněk Rušavý] Summary: It is estimated that up to 3 % of patients with gestational diabetes have glucokinase diabetes, termed also maturity-onset diabetes of the young type 2. The disorder has autosomal dominant inheritance. There is a 50 % risk of transmission of the gene to next generation. Two scenarios with different approach to the treatment may occur in pregnancy with glucokinase diabetes: either the fetus inherits the glucokinase mutation and the treatment of maternal hyperglycemia by insulin could increase the risk of fetal growth restriction, or the fetus is without glucokinase gene mutation and untreated hyperglycemia of the mother increases the risk of macrosomia and perinatal morbidity and insulin therapy is necessary. This article describes the outcome of two pregnancies in a patient with monogenic diabetes with glucokinase deficiency. A specific approach to the treatment is discussed. Springer-Verlag Wien, 2015 Glucokinase diabetes nationallicence Monogenic diabetes nationallicence MODY 2 nationallicence Pregnancy nationallicence Insulin therapy nationallicence Haladová Iva Department of Medicine I, University Hospital and Medical Faculty in Pilsen, Charles University in Prague, Alej Svobody 80, 304 60, Pilsen, Czech Republic aut Čechurová Daniela Department of Medicine I, University Hospital and Medical Faculty in Pilsen, Charles University in Prague, Alej Svobody 80, 304 60, Pilsen, Czech Republic aut Lacigová Silvie Department of Medicine I, University Hospital and Medical Faculty in Pilsen, Charles University in Prague, Alej Svobody 80, 304 60, Pilsen, Czech Republic aut Rušavý Zdeněk Department of Medicine I, University Hospital and Medical Faculty in Pilsen, Charles University in Prague, Alej Svobody 80, 304 60, Pilsen, Czech Republic aut Wiener klinische Wochenschrift Springer Vienna 127/11-12(2015-06-01), 494-496 0043-5325 127:11-12<494 2015 127 508 https://doi.org/10.1007/s00508-015-0795-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00508-015-0795-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Haladová Iva Department of Medicine I, University Hospital and Medical Faculty in Pilsen, Charles University in Prague, Alej Svobody 80, 304 60, Pilsen, Czech Republic aut NATIONALLICENCE 700 1- Čechurová Daniela Department of Medicine I, University Hospital and Medical Faculty in Pilsen, Charles University in Prague, Alej Svobody 80, 304 60, Pilsen, Czech Republic aut NATIONALLICENCE 700 1- Lacigová Silvie Department of Medicine I, University Hospital and Medical Faculty in Pilsen, Charles University in Prague, Alej Svobody 80, 304 60, Pilsen, Czech Republic aut NATIONALLICENCE 700 1- Rušavý Zdeněk Department of Medicine I, University Hospital and Medical Faculty in Pilsen, Charles University in Prague, Alej Svobody 80, 304 60, Pilsen, Czech Republic aut NATIONALLICENCE 773 0- Wiener klinische Wochenschrift Springer Vienna 127/11-12(2015-06-01), 494-496 0043-5325 127:11-12<494 2015 127 508