caa a22 4500 60624106X CHVBK 20210128101311.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00508-014-0690-6 doi (NATIONALLICENCE)springer-10.1007/s00508-014-0690-6 Comparison of diagnostic values of procalcitonin, C-reactive protein and blood neutrophil/lymphocyte ratio levels in predicting bacterial infection in hospitalized patients with acute exacerbations of COPD [Elektronische Daten] [Hakan Tanrıverdi, Tacettin Örnek, Fatma Erboy, Bülent Altınsoy, Fırat Uygur, Figen Atalay, Müge Meltem Tor] Vergleich der diagnostischen Wertigkeit von Procalcitonin, C-reaktivem Protein und vom Neutrophilen/Lymphozyten Quotienten bei der Vorhersage von bakteriellen Infekten bei hospitalisierten Patienten mit akuter Exazerbation einer chronisch obstruktiven Lungenerkrankung Summary: Background: Viral or bacterial upper respiratory infections are the most common cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Based on available data, no reliable parameter has been presented to distinguish between bacterial and nonbacterial exacerbations. Therefore, we compared the diagnostic value of procalcitonin (PCT) level, which is a newer marker for predicting bacterial infections in patients with AECOPD, to routine parameters such as C-reactive protein (CRP) levels and the neutrophil/lymphocyte (N/L) ratio. Methods: This study included all consecutive patients who were admitted for a diagnosis of AECOPD between January 1 and March 31, 2014. PCT, CRP, and the N/L ratio were assessed in addition to cultures from tracheal aspirates or sputum on the first day of admission. Patients with a pneumonic infiltration on chest radiographs, or an extrapulmonary infection focus, or whose blood samples were not obtained for PCT and/or CRP at the same time as sputum culture were excluded from the study. Results: A total of 77 patients were included with a mean age of 71.7±9.5 years. Bacteria were isolated in 37.4% of the patients. Mean PCT levels were significantly higher in patients with positive sputum cultures than in patients with negative sputum cultures. The cut-off values for PCT, CRP, and the N/L ratio for predicting a bacterial infection were 0.40ng/mL, 91.50mg/L, and 11.5, respectively; sensitivity was 61, 54, and 61% respectively; specificity was 67, 52, and 58%, respectively; and the area under the curve (AUC) values were 0.64, 0.52, and 0.58, respectively. The AUC value of PCT was significantly better for predicting bacterial infection compared with the CRP level or the N/L ratio (p=0.042). Conclusion: PCT was better than CRP and the N/L ratio for predicting a bacterial infection in hospitalized patients with AECOPD. However, we find PCT not so reliable in predicting bacterial infection in AECOPD due to sensitivity and specificity of less than 80% and a low AUC value. Springer-Verlag Wien, 2014 COPD nationallicence Procalcitonin nationallicence Exacerbation nationallicence C-reactive protein nationallicence Bacterial infection nationallicence Exazerbation nationallicence C-reaktives Protein nationallicence Bakterielle Infektion nationallicence Tanrıverdi Hakan Faculty of Medicine, Chest Diseases Department, Bülent Ecevit University, Esenköy, Kozlu, 67100, Zonguldak, Turkey aut Örnek Tacettin Faculty of Medicine, Chest Diseases Department, Bülent Ecevit University, Esenköy, Kozlu, 67100, Zonguldak, Turkey aut Erboy Fatma Faculty of Medicine, Chest Diseases Department, Bülent Ecevit University, Esenköy, Kozlu, 67100, Zonguldak, Turkey aut Altınsoy Bülent Faculty of Medicine, Chest Diseases Department, Bülent Ecevit University, Esenköy, Kozlu, 67100, Zonguldak, Turkey aut Uygur Fırat Faculty of Medicine, Chest Diseases Department, Bülent Ecevit University, Esenköy, Kozlu, 67100, Zonguldak, Turkey aut Atalay Figen Faculty of Medicine, Chest Diseases Department, Bülent Ecevit University, Esenköy, Kozlu, 67100, Zonguldak, Turkey aut Tor Müge Meltem Faculty of Medicine, Chest Diseases Department, Bülent Ecevit University, Esenköy, Kozlu, 67100, Zonguldak, Turkey aut Wiener klinische Wochenschrift Springer Vienna 127/19-20(2015-10-01), 756-763 0043-5325 127:19-20<756 2015 127 508 https://doi.org/10.1007/s00508-014-0690-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00508-014-0690-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tanrıverdi Hakan Faculty of Medicine, Chest Diseases Department, Bülent Ecevit University, Esenköy, Kozlu, 67100, Zonguldak, Turkey aut NATIONALLICENCE 700 1- Örnek Tacettin Faculty of Medicine, Chest Diseases Department, Bülent Ecevit University, Esenköy, Kozlu, 67100, Zonguldak, Turkey aut NATIONALLICENCE 700 1- Erboy Fatma Faculty of Medicine, Chest Diseases Department, Bülent Ecevit University, Esenköy, Kozlu, 67100, Zonguldak, Turkey aut NATIONALLICENCE 700 1- Altınsoy Bülent Faculty of Medicine, Chest Diseases Department, Bülent Ecevit University, Esenköy, Kozlu, 67100, Zonguldak, Turkey aut NATIONALLICENCE 700 1- Uygur Fırat Faculty of Medicine, Chest Diseases Department, Bülent Ecevit University, Esenköy, Kozlu, 67100, Zonguldak, Turkey aut NATIONALLICENCE 700 1- Atalay Figen Faculty of Medicine, Chest Diseases Department, Bülent Ecevit University, Esenköy, Kozlu, 67100, Zonguldak, Turkey aut NATIONALLICENCE 700 1- Tor Müge Meltem Faculty of Medicine, Chest Diseases Department, Bülent Ecevit University, Esenköy, Kozlu, 67100, Zonguldak, Turkey aut NATIONALLICENCE 773 0- Wiener klinische Wochenschrift Springer Vienna 127/19-20(2015-10-01), 756-763 0043-5325 127:19-20<756 2015 127 508