caa a22 4500 606241140 CHVBK 20210128101311.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00508-014-0652-z doi (NATIONALLICENCE)springer-10.1007/s00508-014-0652-z Impact of elevated serum estradiol/free testosterone ratio on male varicose veins in a prospective study [Elektronische Daten] [Sedat Özcan, Dolunay Odabasi, Tolga Kurt, Ali Kemal Gür, Aysegul Kunt, Yavuz Balaharoglu, Alper Sami Kunt] Bedeutung eines erhöhten Serum Östradiol/freies Testosteron Quotienten für Varizen beim Mann in einer prospektiven Studie Summary: Objective: Although some studies indicate an association between increased levels of estradiol and varicose veins in women, the role of sex hormones on varicose veins have a question mark in men. Methods: We investigated estradiol-2/free testosterone (E2/fT) ratio relationship on varicosity in 100 male patients dividing them into two groups. Group A (n=46) had varicose veins with endocrinological problems, especially infertility, whereas group B (n=54) also had varicose veins but no endocrinological problems. Venous blood samples were drawn from both groups in the morning to detect the levels of serum estradiol (E2), androstenedione, dehydroepiandrostenedione sulphate and free testosterone (fT). Patient history, physical examination, colour duplex ultrasound of both limbs and classification of CEAP were performed in both groups. Serum E2/fT ratio was calculated in correspondence with CEAP classification. CEAP classification is the varicosity classification, and it is concerned about the clinical class (C), etiology (E), anatomical distribution (A) and underlying pathophysiology (P). Results: E2/fT ratio was significantly higher in group A (4.18±0.54) compared with group B (2.98±0.36). Moreover, there is a high correlation between serum E2/fT ratio and CEAP clinical classification in group A (4) compared with group B (2). Conclusion: Serum E2/fT ratio is associated with varicose veins in male patients. Springer-Verlag Wien, 2014 Varicose veins nationallicence Chronic venous insufficiency nationallicence CEAP classification nationallicence Sex hormones nationallicence Variköse Venen nationallicence Chronisch venöse Insuffizienz nationallicence CEAP Klassifikation nationallicence Sexualhormone nationallicence Özcan Sedat Department of Cardiovascular Surgery, Faculty Of Medicine, 18 Mart University, Canakkale, Turkey aut Odabasi Dolunay Department of Cardiovascular Surgery, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey aut Kurt Tolga Department of Cardiovascular Surgery, Faculty Of Medicine, 18 Mart University, Canakkale, Turkey aut Gür Ali Kemal Department of Cardiovascular Surgery, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey aut Kunt Aysegul Department of Cardiovascular Surgery, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey aut Balaharoglu Yavuz Department of Biochemistry, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey aut Kunt Alper Sami Department of Cardiovascular Surgery, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey aut Wiener klinische Wochenschrift Springer Vienna 127/19-20(2015-10-01), 764-769 0043-5325 127:19-20<764 2015 127 508 https://doi.org/10.1007/s00508-014-0652-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00508-014-0652-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Özcan Sedat Department of Cardiovascular Surgery, Faculty Of Medicine, 18 Mart University, Canakkale, Turkey aut NATIONALLICENCE 700 1- Odabasi Dolunay Department of Cardiovascular Surgery, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey aut NATIONALLICENCE 700 1- Kurt Tolga Department of Cardiovascular Surgery, Faculty Of Medicine, 18 Mart University, Canakkale, Turkey aut NATIONALLICENCE 700 1- Gür Ali Kemal Department of Cardiovascular Surgery, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey aut NATIONALLICENCE 700 1- Kunt Aysegul Department of Cardiovascular Surgery, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey aut NATIONALLICENCE 700 1- Balaharoglu Yavuz Department of Biochemistry, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey aut NATIONALLICENCE 700 1- Kunt Alper Sami Department of Cardiovascular Surgery, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey aut NATIONALLICENCE 773 0- Wiener klinische Wochenschrift Springer Vienna 127/19-20(2015-10-01), 764-769 0043-5325 127:19-20<764 2015 127 508