caa a22 4500 606241256 CHVBK 20210128101312.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00508-015-0824-5 doi (NATIONALLICENCE)springer-10.1007/s00508-015-0824-5 Vitamin D levels and comorbidities in ambulatory and hospitalized patients in Austria [Elektronische Daten] [Christian Muschitz, Roland Kocijan, Verena Stütz, Alexandra Kaider, Gabriela Katharina Muschitz, Heinrich Resch, Stylianos Kapiotis] Summary: Vitamin D in its hormonal active form, 1,25-dihydroxyvitamin D (calcitriol), has a major impact on bone turnover by regulating calcium and phosphate homoeostasis. By binding the active vitamin D hormone to the vitamin D receptor (VDR), it acts as a nuclear transcription factor (Bouillon et al., Endocr Rev 29(6):726-776, 2008). The discovery that almost all tissues and cells in the body express the VDR and that several tissues possess the enzymatic capability to convert 25-hydroxyvitamin D (25(OH)-D3; cholecalciferol) to the active form, suggests that vitamin D fulfills various extra-osseous functions (Bouillon et al., Endocr Rev 29(6):726-776, 2008; Holick, N Engl J Med 357(3):266-281, 2007). For example, VDR ensures adequate intestinal calcium absorption by regulating the synthesis of several calcium transport proteins in the duodenum (Bouillon et al., Endocr Rev 29(6):726-776, 2008). Additionally, vitamin D is important for proper muscle function, and some studies suggest it may contribute to prevent type 1 diabetes mellitus, certain autoimmune diseases, hypertension, and several types of cancer (Holick, N Engl J Med 357(3):266-281, 2007). Springer-Verlag Wien, 2015 Vitamin D deficiency nationallicence Comorbidities nationallicence Age groups nationallicence Cross-sectional study nationallicence Muschitz Christian St. Vincent Hospital, Medical Department II, Academic Teaching Hospital of the Medical University of Vienna, Stumpergasse 13, 1060, Vienna, Austria aut Kocijan Roland St. Vincent Hospital, Medical Department II, Academic Teaching Hospital of the Medical University of Vienna, Stumpergasse 13, 1060, Vienna, Austria aut Stütz Verena Department of Controlling and Medical Statistics, St. Vincent Hospital Vienna, Vienna, Austria aut Kaider Alexandra Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Vienna, Austria aut Muschitz Gabriela Katharina Division of Plastic and Reconstructive Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria aut Resch Heinrich St. Vincent Hospital, Medical Department II, Academic Teaching Hospital of the Medical University of Vienna, Stumpergasse 13, 1060, Vienna, Austria aut Kapiotis Stylianos Labcon—Medical Laboratories Ltd., St. Vincent Group, Vienna, Austria aut Wiener klinische Wochenschrift Springer Vienna 127/17-18(2015-09-01), 675-684 0043-5325 127:17-18<675 2015 127 508 https://doi.org/10.1007/s00508-015-0824-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00508-015-0824-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Muschitz Christian St. Vincent Hospital, Medical Department II, Academic Teaching Hospital of the Medical University of Vienna, Stumpergasse 13, 1060, Vienna, Austria aut NATIONALLICENCE 700 1- Kocijan Roland St. Vincent Hospital, Medical Department II, Academic Teaching Hospital of the Medical University of Vienna, Stumpergasse 13, 1060, Vienna, Austria aut NATIONALLICENCE 700 1- Stütz Verena Department of Controlling and Medical Statistics, St. Vincent Hospital Vienna, Vienna, Austria aut NATIONALLICENCE 700 1- Kaider Alexandra Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Vienna, Austria aut NATIONALLICENCE 700 1- Muschitz Gabriela Katharina Division of Plastic and Reconstructive Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria aut NATIONALLICENCE 700 1- Resch Heinrich St. Vincent Hospital, Medical Department II, Academic Teaching Hospital of the Medical University of Vienna, Stumpergasse 13, 1060, Vienna, Austria aut NATIONALLICENCE 700 1- Kapiotis Stylianos Labcon—Medical Laboratories Ltd., St. Vincent Group, Vienna, Austria aut NATIONALLICENCE 773 0- Wiener klinische Wochenschrift Springer Vienna 127/17-18(2015-09-01), 675-684 0043-5325 127:17-18<675 2015 127 508