caa a22 4500 606241426 CHVBK 20210128101313.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00508-015-0754-2 doi (NATIONALLICENCE)springer-10.1007/s00508-015-0754-2 Real-time shear wave elastography may predict autoimmune thyroid disease [Elektronische Daten] [Mihaela Vlad, Ioana Golu, Simona Bota, Adrian Vlad, Bogdan Timar, Romulus Timar, Ioan Sporea] Summary: Objective: To evaluate and compare the values of the elasticity index as measured by shear wave elastography in healthy subjects and in patients with autoimmune thyroid disease, in order to establish if this investigation can predict the occurrence of autoimmune thyroid disease. Methods: A total of 104 cases were included in the study group: 91 women (87.5 %), out of which 52 (50 %) with autoimmune thyroid disease diagnosed by specific tests and 52 (50 %) healthy volunteers, matched for age and gender. For all the subjects, three measurements were performed on each thyroid lobe and a mean value was calculated. The data were expressed in kPa. The investigation was performed with an Aixplorer system (SuperSonic Imagine, France), using a linear high-resolution 15-4MHz transducer. Results: The mean value for the elasticity index was similar in the right and the left thyroid lobes, both in normal subjects and in patients with autoimmune thyroid disease: 19.6 ± 6.6 vs. 19.5 ± 6.8kPa, p = 0.92, and 26.6 ± 10.0 vs. 25.8 ± 11.7kPa, p = 0.71, respectively. This parameter was significantly higher in patients with autoimmune thyroid disease than in controls (p < 0.001). For a cut-off value of 22.3kPa, which resulted in the highest sum of sensitivity and specificity, the elasticity index assessed by shear wave elastography had a sensitivity of 59.6 % and a specificity of 76.9 % (AUROC = 0.71; p < 0.001) for predicting the presence of autoimmune thyroid disease. Conclusion: Quantitative elasticity index measured by shear wave elastography was significantly higher in autoimmune thyroid disease than in normal thyroid parenchyma and may predict the presence of autoimmune thyroid disease. Springer-Verlag Wien, 2015 Shear wave elastography nationallicence Autoimmune thyroid disease nationallicence Prediction nationallicence Vlad Mihaela Department of Endocrinology, "Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania aut Golu Ioana Department of Endocrinology, "Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania aut Bota Simona Department of Gastroenterology, "Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania aut Vlad Adrian Department of Diabetes and Metabolic Diseases, "Victor Babes” University of Medicine and Pharmacy, P-ta Eftimie Murgu 2, 300041, Timisoara, Romania aut Timar Bogdan Department of Biostatistics and Medical Informatics, "Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania aut Timar Romulus Department of Gastroenterology, "Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania aut Sporea Ioan Department of Gastroenterology, "Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania aut Wiener klinische Wochenschrift Springer Vienna 127/9-10(2015-05-01), 330-336 0043-5325 127:9-10<330 2015 127 508 https://doi.org/10.1007/s00508-015-0754-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00508-015-0754-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vlad Mihaela Department of Endocrinology, "Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania aut NATIONALLICENCE 700 1- Golu Ioana Department of Endocrinology, "Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania aut NATIONALLICENCE 700 1- Bota Simona Department of Gastroenterology, "Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania aut NATIONALLICENCE 700 1- Vlad Adrian Department of Diabetes and Metabolic Diseases, "Victor Babes” University of Medicine and Pharmacy, P-ta Eftimie Murgu 2, 300041, Timisoara, Romania aut NATIONALLICENCE 700 1- Timar Bogdan Department of Biostatistics and Medical Informatics, "Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania aut NATIONALLICENCE 700 1- Timar Romulus Department of Gastroenterology, "Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania aut NATIONALLICENCE 700 1- Sporea Ioan Department of Gastroenterology, "Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania aut NATIONALLICENCE 773 0- Wiener klinische Wochenschrift Springer Vienna 127/9-10(2015-05-01), 330-336 0043-5325 127:9-10<330 2015 127 508