caa a22 4500 606242465 CHVBK 20210128101318.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s12602-014-9176-0 doi (NATIONALLICENCE)springer-10.1007/s12602-014-9176-0 Local Probiotic Therapy for Vaginal Candida albicans Infections [Elektronische Daten] [Stefan Kovachev, Rossitza Vatcheva-Dobrevska] The high rate of vaginal Candida albicans recurrence is attributed to azole resistance rates as high as 15%. The aim of this study was to determine the clinical and microbiological efficacy of standard azole therapy for treatment of vaginal C. albicans infection alone and in combination with local probiotic as well as the effects on vaginal microbiota. This study included 436 women with vaginal candidiasis randomly assigned to two treatment groups. The first group, with 207 patients (12 dropouts), was administered 150mg fluconazole and a single vaginal globule of fenticonazole (600mg) on the same day. The second group of 209 patients (8 dropouts) followed the same treatment schedule; however, ten applications of a vaginal probiotic containing Lactobacillus acidophilus, L. rhamnosus, Streptococcus thermophilus, and L. delbrueckii subsp. bulgaricus were also administered beginning the fifth day after azole treatment. Microbiological analysis of the therapy efficacy in the first treatment group showed C. albicans resistance in over 30% of patients. Clinical complaints persisted after treatment administration in 79.7% (n=165) of women in this group. Clinical complaints in the second group decreased to 31.1% (n=65) and microbiological efficacy also improved among investigated parameters, from 93.7% (n=193) to 95.2% (n=198). The local application of probiotics after administration of combined azoles for treatment of vaginal C. albicans infections increases therapy efficacy and could prevent relapse. Springer Science+Business Media New York, 2014 Lactobacilli nationallicence Vaginal Candida albicans nationallicence Azoles nationallicence Probiotic nationallicence Kovachev Stefan Department of Gynecology, Military Medical Academy, G. Sofijsky Str. 3, 1600, Sofia, Bulgaria aut Vatcheva-Dobrevska Rossitza Department of Microbiology and Virology, University Hospital Queen Joanna- ISUL, Bialo More Str. 8, 1527, Sofia, Bulgaria aut Probiotics and Antimicrobial Proteins Springer US; http://www.springer-ny.com 7/1(2015-03-01), 38-44 1867-1306 7:1<38 2015 7 12602 https://doi.org/10.1007/s12602-014-9176-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12602-014-9176-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kovachev Stefan Department of Gynecology, Military Medical Academy, G. Sofijsky Str. 3, 1600, Sofia, Bulgaria aut NATIONALLICENCE 700 1- Vatcheva-Dobrevska Rossitza Department of Microbiology and Virology, University Hospital Queen Joanna- ISUL, Bialo More Str. 8, 1527, Sofia, Bulgaria aut NATIONALLICENCE 773 0- Probiotics and Antimicrobial Proteins Springer US; http://www.springer-ny.com 7/1(2015-03-01), 38-44 1867-1306 7:1<38 2015 7 12602