caa a22 4500 606242740 CHVBK 20210128101320.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s12551-014-0148-0 doi (NATIONALLICENCE)springer-10.1007/s12551-014-0148-0 Cardiac stem cells: translation to human studies [Elektronische Daten] [Zijun Ge, Sean Lal, Thi Le, Cris dos Remedios, James Chong] The discovery of multiple classes of cardiac progenitor cells in the adult mammalian heart has generated hope for their use as a therapeutic in heart failure. However, successful results from animal models have not always yielded similar findings in human studies. Recent Phase I/II trials of c-Kit (SCIPIO) and cardiosphere-based (CADUCEUS) cardiac progenitor cells have demonstrated safety and some therapeutic efficacy. Gaps remain in our understanding of the origins, function and relationships between the different progenitor cell families, many of which are heterogeneous populations with overlapping definitions. Another challenge lies in the limitations of small animal models in replicating the human heart. Cryopreserved human cardiac tissue provides a readily available source of cardiac progenitor cells and may help address these questions. We review important findings and relative unknowns of the main classes of cardiac progenitor cells, highlighting differences between animal and human studies International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag Berlin Heidelberg, 2014 Cardiac stem cells nationallicence Human cardiac tissue nationallicence Cryopreservation nationallicence Cardiac progenitor cells nationallicence Ge Zijun Bosch Institute, The University of Sydney, Sydney, Australia aut Lal Sean Bosch Institute, The University of Sydney, Sydney, Australia aut Le Thi Department of Cardiology Westmead Hospital, Sydney, NSW, Australia aut dos Remedios Cris Bosch Institute, The University of Sydney, Sydney, Australia aut Chong James Department of Cardiology Westmead Hospital, Sydney, NSW, Australia aut Biophysical Reviews Springer Berlin Heidelberg 7/1(2015-03-01), 127-139 1867-2450 7:1<127 2015 7 12551 https://doi.org/10.1007/s12551-014-0148-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12551-014-0148-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ge Zijun Bosch Institute, The University of Sydney, Sydney, Australia aut NATIONALLICENCE 700 1- Lal Sean Bosch Institute, The University of Sydney, Sydney, Australia aut NATIONALLICENCE 700 1- Le Thi Department of Cardiology Westmead Hospital, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- dos Remedios Cris Bosch Institute, The University of Sydney, Sydney, Australia aut NATIONALLICENCE 700 1- Chong James Department of Cardiology Westmead Hospital, Sydney, NSW, Australia aut NATIONALLICENCE 773 0- Biophysical Reviews Springer Berlin Heidelberg 7/1(2015-03-01), 127-139 1867-2450 7:1<127 2015 7 12551