caa a22 4500 606242791 CHVBK 20210128101320.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s12551-014-0158-y doi (NATIONALLICENCE)springer-10.1007/s12551-014-0158-y The role of TGFβ1 and LRG1 in cardiac remodelling and heart failure [Elektronische Daten] [Weihua Song, Xiaomeng Wang] Heart failure is a life-threatening condition that carries a considerable emotional and socio-economic burden. As a result of the global increase in the ageing population, sedentary life-style, increased prevalence of risk factors, and improved survival from cardiovascular events, the incidence of heart failure will continue to rise. Despite the advances in current cardiovascular therapies, many patients are not suitable for or may not benefit from conventional treatments. Thus, more effective therapies are required. Transforming growth factor (TGF) β family of cytokines is involved in heart development and dys-regulated TGFβ signalling is commonly associated with fibrosis, aberrant angiogenesis and accelerated progression into heart failure. Therefore, a potential therapeutic pathway is to modulate TGFβ signalling; however, broad blockage of TGFβ signalling may cause unwanted side effects due to its pivotal role in tissue homeostasis. We found that leucine-rich α-2 glycoprotein 1 (LRG1) promotes blood vessel formation via regulating the context-dependent endothelial TGFβ signalling. This review will focus on the interaction between LRG1 and TGFβ signalling, their involvement in the pathogenesis of heart failure, and the potential for LRG1 to function as a novel therapeutic target. The Author(s), 2015 LRG1 nationallicence TGFβ nationallicence Cardiac remodelling nationallicence Therapeutic angiogenesis nationallicence Fibrosis nationallicence Heart failure nationallicence Song Weihua Division of Metabolic Medicine, Lee Kong Chian School of Medicine, Nanyang Technological University, Research Techno Plaza, X-Frontiers Block, Level 4, 50 Nan yang Drive, 637553, Singapore, Singapore aut Wang Xiaomeng Division of Metabolic Medicine, Lee Kong Chian School of Medicine, Nanyang Technological University, Research Techno Plaza, X-Frontiers Block, Level 4, 50 Nan yang Drive, 637553, Singapore, Singapore aut Biophysical Reviews Springer Berlin Heidelberg 7/1(2015-03-01), 91-104 1867-2450 7:1<91 2015 7 12551 https://doi.org/10.1007/s12551-014-0158-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12551-014-0158-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Song Weihua Division of Metabolic Medicine, Lee Kong Chian School of Medicine, Nanyang Technological University, Research Techno Plaza, X-Frontiers Block, Level 4, 50 Nan yang Drive, 637553, Singapore, Singapore aut NATIONALLICENCE 700 1- Wang Xiaomeng Division of Metabolic Medicine, Lee Kong Chian School of Medicine, Nanyang Technological University, Research Techno Plaza, X-Frontiers Block, Level 4, 50 Nan yang Drive, 637553, Singapore, Singapore aut NATIONALLICENCE 773 0- Biophysical Reviews Springer Berlin Heidelberg 7/1(2015-03-01), 91-104 1867-2450 7:1<91 2015 7 12551