caa a22 4500 606242805 CHVBK 20210128101320.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s12551-014-0154-2 doi (NATIONALLICENCE)springer-10.1007/s12551-014-0154-2 G protein-coupled receptors in cardiac biology: old and new receptors [Elektronische Daten] [Simon Foster, Eugeni Roura, Peter Molenaar, Walter Thomas] G protein-coupled receptors (GPCRs) are seven-transmembrane-spanning proteins that mediate cellular and physiological responses. They are critical for cardiovascular function and are targeted for the treatment of hypertension and heart failure. Nevertheless, current therapies only target a small fraction of the cardiac GPCR repertoire, indicating that there are many opportunities to investigate unappreciated aspects of heart biology. Here, we offer an update on the contemporary view of GPCRs and the complexities of their signalling, and review the roles of the ‘classical' GPCRs in cardiovascular physiology and disease. We then provide insights into other GPCRs that have been less extensively studied in the heart, including orphan, odorant and taste receptors. We contend that these novel cardiac GPCRs contribute to heart function in health and disease and thereby offer exciting opportunities to therapeutically modulate heart function. International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag Berlin Heidelberg, 2015 G protein-coupled receptor nationallicence Heart nationallicence Cardiovascular disease nationallicence Orphan receptor nationallicence Odorant receptor nationallicence Taste receptor nationallicence Foster Simon School of Biomedical Sciences, University of Queensland, St Lucia Campus, 4072, Brisbane, Australia aut Roura Eugeni School of Biomedical Sciences, University of Queensland, St Lucia Campus, 4072, Brisbane, Australia aut Molenaar Peter Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, St Lucia Campus, Brisbane, Australia aut Thomas Walter School of Biomedical Sciences, University of Queensland, St Lucia Campus, 4072, Brisbane, Australia aut Biophysical Reviews Springer Berlin Heidelberg 7/1(2015-03-01), 77-89 1867-2450 7:1<77 2015 7 12551 https://doi.org/10.1007/s12551-014-0154-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12551-014-0154-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Foster Simon School of Biomedical Sciences, University of Queensland, St Lucia Campus, 4072, Brisbane, Australia aut NATIONALLICENCE 700 1- Roura Eugeni School of Biomedical Sciences, University of Queensland, St Lucia Campus, 4072, Brisbane, Australia aut NATIONALLICENCE 700 1- Molenaar Peter Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, St Lucia Campus, Brisbane, Australia aut NATIONALLICENCE 700 1- Thomas Walter School of Biomedical Sciences, University of Queensland, St Lucia Campus, 4072, Brisbane, Australia aut NATIONALLICENCE 773 0- Biophysical Reviews Springer Berlin Heidelberg 7/1(2015-03-01), 77-89 1867-2450 7:1<77 2015 7 12551