caa a22 4500 606242848 CHVBK 20210128101320.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s12551-014-0146-2 doi (NATIONALLICENCE)springer-10.1007/s12551-014-0146-2 Adaptations of cytoarchitecture in human dilated cardiomyopathy [Elektronische Daten] [Marlene Pluess, Gregor Daeubler, Cristobal dos Remedios, Elisabeth Ehler] Hypertrophic cardiomyopathy is characterised by a histological phenotype of myocyte disarray, but heart tissue samples from patients with dilated cardiomyopathy (DCM) often look comparatively similar to those from healthy individuals apart from conspicuous regions of fibrosis and necrosis. We have previously investigated subcellular alterations in the cytoarchitecture of mouse models of dilated cardiomyopathy and found that both the organisation and composition of the intercalated disc, i.e. the specialised type of cell-cell contact in the heart, is altered. There is also is a change in the composition of the M-band of the sarcomere due to an expression shift towards the more extensible embryonic heart (EH)-myomesin isoform. Analysis of human samples from the Sydney Human Heart Tissue Bank have revealed similar structural findings and also provided evidence for a dramatic change in overall cardiomyocyte size control, which has also been seen in the mouse. Together these changes in cytoarchitecture probably contribute to the decreased functional output that is seen in DCM. The Author(s), 2014 Cytoskeleton nationallicence Intercalated disc nationallicence Dilated cardiomyopathy nationallicence Formin nationallicence M-band nationallicence Pluess Marlene Randall Division of Cell and Molecular Biophysics and Cardiovascular Division, British Heart Foundation Centre of Research Excellence, King's College London, New Hunt's House, Guy's Campus, SE1 1UL, London, UK aut Daeubler Gregor Randall Division of Cell and Molecular Biophysics and Cardiovascular Division, British Heart Foundation Centre of Research Excellence, King's College London, New Hunt's House, Guy's Campus, SE1 1UL, London, UK aut dos Remedios Cristobal Bosch Institute, Department of Anatomy, University of Sydney, 2006, Sydney, Australia aut Ehler Elisabeth Randall Division of Cell and Molecular Biophysics and Cardiovascular Division, British Heart Foundation Centre of Research Excellence, King's College London, New Hunt's House, Guy's Campus, SE1 1UL, London, UK aut Biophysical Reviews Springer Berlin Heidelberg 7/1(2015-03-01), 25-32 1867-2450 7:1<25 2015 7 12551 https://doi.org/10.1007/s12551-014-0146-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12551-014-0146-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pluess Marlene Randall Division of Cell and Molecular Biophysics and Cardiovascular Division, British Heart Foundation Centre of Research Excellence, King's College London, New Hunt's House, Guy's Campus, SE1 1UL, London, UK aut NATIONALLICENCE 700 1- Daeubler Gregor Randall Division of Cell and Molecular Biophysics and Cardiovascular Division, British Heart Foundation Centre of Research Excellence, King's College London, New Hunt's House, Guy's Campus, SE1 1UL, London, UK aut NATIONALLICENCE 700 1- dos Remedios Cristobal Bosch Institute, Department of Anatomy, University of Sydney, 2006, Sydney, Australia aut NATIONALLICENCE 700 1- Ehler Elisabeth Randall Division of Cell and Molecular Biophysics and Cardiovascular Division, British Heart Foundation Centre of Research Excellence, King's College London, New Hunt's House, Guy's Campus, SE1 1UL, London, UK aut NATIONALLICENCE 773 0- Biophysical Reviews Springer Berlin Heidelberg 7/1(2015-03-01), 25-32 1867-2450 7:1<25 2015 7 12551