caa a22 4500 606242945 CHVBK 20210128101321.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s12551-015-0178-2 doi (NATIONALLICENCE)springer-10.1007/s12551-015-0178-2 A critical analysis of cancer biobank practices in relation to biospecimen quality [Elektronische Daten] [Amanda Rush, Kevin Spring, Jennifer Byrne] There are concerns that a substantial proportion of published research data is not reproducible, which may partially explain the frequent failure to translate pre-clinical results to clinical care. High-quality cancer biospecimens are needed for robust, reproducible research findings, with most researchers obtaining these specimens from cancer biobanks or tumour banks. This review provides an overview of the types of quality control (QC) activities conducted within cancer biobanks that pertain to biospecimen quality and of biospecimen quality reporting tools, including SPREC and BRISQ. We examine how QC assay results and other biospecimen data are communicated from biobanks to researchers, and whether these activities lead to improved biospecimen quality reporting within the literature and/or to improved research outcomes. We also discuss operational factors that limit QC activities within biobanks and evidence gaps requiring further research. In summary, whereas the provision of quality biospecimens is a common aim of cancer biobanks, QC activities remain underreported and are rarely discussed in the literature, compared with other aspects of biobank operations. Further research is required to determine how biobanks can most efficiently optimise biospecimen quality, and how communication between biobanks and researchers can be improved. International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag Berlin Heidelberg, 2015 Biobank nationallicence Cancer nationallicence Biospecimen quality nationallicence Research reproducibility nationallicence Quality control nationallicence Reporting nationallicence Rush Amanda Molecular Oncology Laboratory, Children's Cancer Research Unit, Kids Research Institute, The Children's Hospital at Westmead, Locked Bag 4001, 2145, Westmead, NSW, Australia aut Spring Kevin Ingham Institute, PO Box 3151 (Westfield Liverpool), 2170, Liverpool, NSW, Australia aut Byrne Jennifer Molecular Oncology Laboratory, Children's Cancer Research Unit, Kids Research Institute, The Children's Hospital at Westmead, Locked Bag 4001, 2145, Westmead, NSW, Australia aut Biophysical Reviews Springer Berlin Heidelberg 7/4(2015-12-01), 369-378 1867-2450 7:4<369 2015 7 12551 https://doi.org/10.1007/s12551-015-0178-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12551-015-0178-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rush Amanda Molecular Oncology Laboratory, Children's Cancer Research Unit, Kids Research Institute, The Children's Hospital at Westmead, Locked Bag 4001, 2145, Westmead, NSW, Australia aut NATIONALLICENCE 700 1- Spring Kevin Ingham Institute, PO Box 3151 (Westfield Liverpool), 2170, Liverpool, NSW, Australia aut NATIONALLICENCE 700 1- Byrne Jennifer Molecular Oncology Laboratory, Children's Cancer Research Unit, Kids Research Institute, The Children's Hospital at Westmead, Locked Bag 4001, 2145, Westmead, NSW, Australia aut NATIONALLICENCE 773 0- Biophysical Reviews Springer Berlin Heidelberg 7/4(2015-12-01), 369-378 1867-2450 7:4<369 2015 7 12551