caa a22 4500 606242953 CHVBK 20210128101321.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s12551-015-0184-4 doi (NATIONALLICENCE)springer-10.1007/s12551-015-0184-4 Historical perspective on heart function: the Frank-Starling Law [Elektronische Daten] [Vasco Sequeira, Jolanda van der Velden] More than a century of research on the Frank-Starling Law has significantly advanced our knowledge about the working heart. The Frank-Starling Law mandates that the heart is able to match cardiac ejection to the dynamic changes occurring in ventricular filling and thereby regulates ventricular contraction and ejection. Significant efforts have been attempted to identify a common fundamental basis for the Frank-Starling heart and, although a unifying idea has still to come forth, there is mounting evidence of a direct relationship between length changes in individual constituents (cardiomyocytes) and their sensitivity to Ca2+ ions. As the Frank-Starling Law is a vital event for the healthy heart, it is of utmost importance to understand its mechanical basis in order to optimize and organize therapeutic strategies to rescue the failing human heart. The present review is a historic perspective on cardiac muscle function. We "revive” a century of scientific research on the heart's fundamental protein constituents (contractile proteins), to their assemblies in the muscle (the sarcomeres), culminating in a thorough overview of the several synergistically events that compose the Frank-Starling mechanism. It is the authors' personal beliefs that much can be gained by understanding the Frank-Starling relationship at the cellular and whole organ level, so that we can finally, in this century, tackle the pathophysiologic mechanisms underlying heart failure. International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag Berlin Heidelberg, 2015 Frank-Starling nationallicence Heart nationallicence Cardiomyocytes nationallicence Myofilaments nationallicence History nationallicence Sequeira Vasco Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands aut van der Velden Jolanda Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands aut Biophysical Reviews Springer Berlin Heidelberg 7/4(2015-12-01), 421-447 1867-2450 7:4<421 2015 7 12551 https://doi.org/10.1007/s12551-015-0184-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12551-015-0184-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sequeira Vasco Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- van der Velden Jolanda Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands aut NATIONALLICENCE 773 0- Biophysical Reviews Springer Berlin Heidelberg 7/4(2015-12-01), 421-447 1867-2450 7:4<421 2015 7 12551