caa a22 4500 606242961 CHVBK 20210128101321.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s12551-015-0180-8 doi (NATIONALLICENCE)springer-10.1007/s12551-015-0180-8 Liposomal systems as carriers for bioactive compounds [Elektronische Daten] [Ana Simão, Maytê Bolean, Thuanny Cury, Rodrigo Stabeli, Rosangela Itri, Pietro Ciancaglini] Since the revolutionary discovery that phospholipids can form closed bilayered structures in aqueous systems, the study of liposomes has become a very interesting area of research. The versatility and amazing biocompatibility of liposomes has resulted in their wide-spread use in many scientific fields, and many of their applications, especially in medicine, have yielded breakthroughs in recent decades. Specifically, their easy preparation and various structural aspects have given rise to broadly usable methodologies to internalize different compounds, with either lipophilic or hydrophilic properties. The study of compounds with potential biotechnological application(s) is generally related to evaluation and risk assessment of the possible cytotoxic or therapeutic effects of the compound under study. In most cases, undesirable side-effects are associated with an interaction of the liposome with the cell membrane and/or its absorption and subsequent interaction with a cellular biomolecule. Liposomal carrier systems have an unprecedented potential for delivering bioactive substances to specific molecular targets due to their biocompatibility, biodegradability and low toxicity. Liposomes are therefore considered to be an invaluable asset in applied biotechnology studies due to their potential for interaction with both hydrophilic and lipophilic compounds. International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag Berlin Heidelberg, 2015 Biotechnology nationallicence Carrier nationallicence Drugs nationallicence Liposome nationallicence Delivery nationallicence Simão Ana Departmento de Química, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto (FFCLRP), Universidade de São Paulo (USP), Av. Bandeirantes, 3900, 14040-901, Ribeirão Preto, SP, Brazil aut Bolean Maytê Departmento de Química, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto (FFCLRP), Universidade de São Paulo (USP), Av. Bandeirantes, 3900, 14040-901, Ribeirão Preto, SP, Brazil aut Cury Thuanny Departmento de Química, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto (FFCLRP), Universidade de São Paulo (USP), Av. Bandeirantes, 3900, 14040-901, Ribeirão Preto, SP, Brazil aut Stabeli Rodrigo Centro de Nanotecnologia Aplicada a Saúde-Nanosus, Presidência da Fiocruz, Rua Prof. Algacyr Munhoz Mader, 3775, 81350-010, Curitiba, PR, Brazil aut Itri Rosangela Depto. Física Aplicada, Instituto de Física, IF-USP, São Paulo, SP, Brazil aut Ciancaglini Pietro Departmento de Química, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto (FFCLRP), Universidade de São Paulo (USP), Av. Bandeirantes, 3900, 14040-901, Ribeirão Preto, SP, Brazil aut Biophysical Reviews Springer Berlin Heidelberg 7/4(2015-12-01), 391-397 1867-2450 7:4<391 2015 7 12551 https://doi.org/10.1007/s12551-015-0180-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12551-015-0180-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Simão Ana Departmento de Química, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto (FFCLRP), Universidade de São Paulo (USP), Av. Bandeirantes, 3900, 14040-901, Ribeirão Preto, SP, Brazil aut NATIONALLICENCE 700 1- Bolean Maytê Departmento de Química, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto (FFCLRP), Universidade de São Paulo (USP), Av. Bandeirantes, 3900, 14040-901, Ribeirão Preto, SP, Brazil aut NATIONALLICENCE 700 1- Cury Thuanny Departmento de Química, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto (FFCLRP), Universidade de São Paulo (USP), Av. Bandeirantes, 3900, 14040-901, Ribeirão Preto, SP, Brazil aut NATIONALLICENCE 700 1- Stabeli Rodrigo Centro de Nanotecnologia Aplicada a Saúde-Nanosus, Presidência da Fiocruz, Rua Prof. Algacyr Munhoz Mader, 3775, 81350-010, Curitiba, PR, Brazil aut NATIONALLICENCE 700 1- Itri Rosangela Depto. Física Aplicada, Instituto de Física, IF-USP, São Paulo, SP, Brazil aut NATIONALLICENCE 700 1- Ciancaglini Pietro Departmento de Química, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto (FFCLRP), Universidade de São Paulo (USP), Av. Bandeirantes, 3900, 14040-901, Ribeirão Preto, SP, Brazil aut NATIONALLICENCE 773 0- Biophysical Reviews Springer Berlin Heidelberg 7/4(2015-12-01), 391-397 1867-2450 7:4<391 2015 7 12551