caa a22 4500 606243046 CHVBK 20210128101322.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s12551-015-0168-4 doi (NATIONALLICENCE)springer-10.1007/s12551-015-0168-4 Terahertz optical measurements of correlated motions with possible allosteric function [Elektronische Daten] [Katherine Niessen, Mengyang Xu, A. Markelz] A suggested mechanism for allosteric response is the distortion of the energy landscape with agonist binding changing the protein structure's access to functional configurations. Intramolecular vibrations are indicative of the energy landscape and may have trajectories that enable functional conformational change. Here, we discuss the development of an optical method to measure the intramolecular vibrations in proteins, namely, crystal anisotropy terahertz microscopy, and the various approaches which can be used to identify the spectral data with specific structural motions. International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag Berlin Heidelberg, 2015 Allosteric response nationallicence Proteins nationallicence Vibrational modes nationallicence Functional configurations nationallicence Terahertz nationallicence Normal modes nationallicence Far infrared nationallicence Niessen Katherine Department of Physics, University at Buffalo (SUNY), 14260, Buffalo, NY, USA aut Xu Mengyang Department of Physics, University at Buffalo (SUNY), 14260, Buffalo, NY, USA aut Markelz A. Department of Physics, University at Buffalo (SUNY), 14260, Buffalo, NY, USA aut Biophysical Reviews Springer Berlin Heidelberg 7/2(2015-06-01), 201-216 1867-2450 7:2<201 2015 7 12551 https://doi.org/10.1007/s12551-015-0168-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12551-015-0168-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Niessen Katherine Department of Physics, University at Buffalo (SUNY), 14260, Buffalo, NY, USA aut NATIONALLICENCE 700 1- Xu Mengyang Department of Physics, University at Buffalo (SUNY), 14260, Buffalo, NY, USA aut NATIONALLICENCE 700 1- Markelz A. Department of Physics, University at Buffalo (SUNY), 14260, Buffalo, NY, USA aut NATIONALLICENCE 773 0- Biophysical Reviews Springer Berlin Heidelberg 7/2(2015-06-01), 201-216 1867-2450 7:2<201 2015 7 12551