caa a22 4500 60624316X CHVBK 20210128101323.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s11694-014-9211-6 doi (NATIONALLICENCE)springer-10.1007/s11694-014-9211-6 In vitro antioxidant, brine shrimp lethality and antimicrobial activities of methanol and petroleum ether extracts of Cassia renigera fruit [Elektronische Daten] [Md. Hossain, Milon Mondal, Md. Hossain, Md. Uddin, Nizam Uddin, Md. Hasan, Md. Hossain, A. Mahmudul Islam, Md. Rana] Cassia renigera (C. renigera) is an evergreen tree (family Caesalpiniaceae) is locally known as Minjiri (Bengali). It is locally used as a medicinal plant. In this study we investigated antioxidant, brine shrimp lethality and antimicrobial activities of the fruit extracts of this plant using different in vitro assay models. Methanol extract showed better activities than petroleum ether extract in total phenol, total flavonoid and total antioxidant capacity assays. Besides, methanol extract also showed higher 1,1-diphenyl-2-picrylhydrazyl (DPPH) and Nitric oxide radical scavenging activities than petroleum ether extract. In cupric reducing and reducing power capacity assays methanol extract exhibited dose dependent reducing capacity. In brine shrimp lethality bioassay petroleum ether extract (LC50 of 89.385μg/mL, χ2=215.968, p<0.05) was found to be more potent than methanol extract (LC50 of 128.042μg/mL, χ2=235.274, p<0.05). In disk diffusion technique, it was observed that Gram positive bacteria are more susceptible than Gram negative bacteria. Both extracts showed broad spectrum antimicrobial activity. Methanol extract showed antibacterial activity against all tested microorganisms. The highest activity (minimum zone of inhibition 11.25±0.35mm) was exhibited by methanol extract against Bacillus cerus. No activity was observed against Escherichia coli and Shigella dysenteriae by petroleum ether extract. In a nutshell, it is suggested that the fruit can be used as a potential source for the above mentioned bioactivities. That is why extensive researches may be carried out to investigate the active principles responsible for these activities. Springer Science+Business Media New York, 2014 Cassia renigera nationallicence Antioxidant activity nationallicence Brine shrimp lethality nationallicence DPPH nationallicence Antibacterial activity nationallicence Hossain Md Department of Pharmacy, Jahangirnagar University, Savar, 1342, Dhaka, Bangladesh aut Mondal Milon Department of Pharmacy, Jahangirnagar University, Savar, 1342, Dhaka, Bangladesh aut Uddin Md Department of Pharmacy, Jahangirnagar University, Savar, 1342, Dhaka, Bangladesh aut Uddin Nizam Department of Pharmacy, Jahangirnagar University, Savar, 1342, Dhaka, Bangladesh aut Hasan Md Department of Pharmacy, Jahangirnagar University, Savar, 1342, Dhaka, Bangladesh aut Mahmudul Islam A. Department of Pharmacy, Jahangirnagar University, Savar, 1342, Dhaka, Bangladesh aut Rana Md Department of Pharmacy, Jahangirnagar University, Savar, 1342, Dhaka, Bangladesh aut Journal of Food Measurement and Characterization Springer US; http://www.springer-ny.com 9/1(2015-03-01), 68-75 2193-4126 9:1<68 2015 9 11694 https://doi.org/10.1007/s11694-014-9211-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11694-014-9211-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hossain Md Department of Pharmacy, Jahangirnagar University, Savar, 1342, Dhaka, Bangladesh aut NATIONALLICENCE 700 1- Mondal Milon Department of Pharmacy, Jahangirnagar University, Savar, 1342, Dhaka, Bangladesh aut NATIONALLICENCE 700 1- Uddin Md Department of Pharmacy, Jahangirnagar University, Savar, 1342, Dhaka, Bangladesh aut NATIONALLICENCE 700 1- Uddin Nizam Department of Pharmacy, Jahangirnagar University, Savar, 1342, Dhaka, Bangladesh aut NATIONALLICENCE 700 1- Hasan Md Department of Pharmacy, Jahangirnagar University, Savar, 1342, Dhaka, Bangladesh aut NATIONALLICENCE 700 1- Mahmudul Islam A. Department of Pharmacy, Jahangirnagar University, Savar, 1342, Dhaka, Bangladesh aut NATIONALLICENCE 700 1- Rana Md Department of Pharmacy, Jahangirnagar University, Savar, 1342, Dhaka, Bangladesh aut NATIONALLICENCE 773 0- Journal of Food Measurement and Characterization Springer US; http://www.springer-ny.com 9/1(2015-03-01), 68-75 2193-4126 9:1<68 2015 9 11694