caa a22 4500 606245235 CHVBK 20210128101334.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s12262-012-0741-z doi (NATIONALLICENCE)springer-10.1007/s12262-012-0741-z Can Subepididymal Orchiectomy Re-emerge as the Treatment of Choice in Patients with Advanced Prostatic Carcinoma? [Elektronische Daten] [Mayank Agarwal, Madhu Agrawal] To study the effectiveness of bilateral subepididymal orchiectomy compared to bilateral simple and subcapsular orchiectomy in terms of androgen ablation, control of disease progression and esthetic superiority. 114 patients of advanced prostatic carcinoma (T3, T4, M1) were randomized to 3 groups- Group A: bilateral simple orchiectomy (38 patients), Group B: bilateral subcapsular orchiectomy (38 patients), & Group C: bilateral subepididymal orchiectomy (38 patients). Serum PSA and serum testosterone values were checked pre-operatively and at 3months follow-up. Patients' esthetic satisfaction was scored on a quality of life scale of 1-5. In Groups A, B and C, at 3months the post-operative mean serum testosterone values were 34.7, 38.1 and 36.7ng/dl (p = 0.0524); and mean serum PSA values were 4.2, 3.9 and 3.4ng/ml (p = 0.09) respectively, the differences not being statistically significant. On esthetic satisfaction scale the average scores were 1.8, 2.7 and 4.0 respectively, the difference being highly significant (p < 0.0001). Subepididymal orchiectomy maintains esthetic appearance of scrotum and provides superior patient satisfaction as compared to standard total and subcapsular orchiectomy, while achieving equal efficacy. Bilateral sub-epididymal orchiectomy may thus be considered procedure of choice to achieve androgen ablation in advanced prostatic carcinoma. Association of Surgeons of India, 2012 Epididymis nationallicence Orchiectomy nationallicence Prostatic neoplasms nationallicence Testis nationallicence Agarwal Mayank Department of Surgery, S. N. Medical College, Agra, India aut Agrawal Madhu Urology Division, Department of Surgery, SN Medical College, 282002, Agra, Uttar Pradesh, India aut Indian Journal of Surgery Springer India 77/1(2015-02-01), 23-27 0972-2068 77:1<23 2015 77 12262 https://doi.org/10.1007/s12262-012-0741-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12262-012-0741-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Agarwal Mayank Department of Surgery, S. N. Medical College, Agra, India aut NATIONALLICENCE 700 1- Agrawal Madhu Urology Division, Department of Surgery, SN Medical College, 282002, Agra, Uttar Pradesh, India aut NATIONALLICENCE 773 0- Indian Journal of Surgery Springer India 77/1(2015-02-01), 23-27 0972-2068 77:1<23 2015 77 12262