caa a22 4500 606245367 CHVBK 20210128101335.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s12262-013-0817-4 doi (NATIONALLICENCE)springer-10.1007/s12262-013-0817-4 Palliative Radiotherapy in Esophageal Cancer [Elektronische Daten] [N. Prasad, M. Karthigeyan, Kate Vikram, R. Parthasarathy, K. Reddy] The present study was undertaken to evaluate the efficacy of radiotherapy in palliation of dysphagia in patients with squamous cell carcinoma (SCC) of esophagus and to see the quality of life (QoL) following radiotherapy. This was a prospective clinical study done between September 2006 and May 2008. All consecutive patients with SCC of the esophagus, who are not candidates for definitive treatment, were included in the study. Dysphagia and QoL were assessed using modified Takita's grading and modified questionnaire based on EORTC QLQ 30 respectively. External beam radiotherapy (EBRT) was delivered to all patients using linear accelerator 6 Mv photons. Patients who had good response with EBRT were further subjected to intraluminal brachytherapy (ILBT) at 700cGy using Iridium-192. The cumulative dose each patient received was 65Gy. Patients were followed up at 6weeks from completion of treatment to look for any difference in dysphagia grade and QoL following therapy. Thirty-three patients were included in the study. The mean age among males and females was 60.9 and 49.8years, respectively. Nineteen patients (57.6%) received EBRT followed by ILBT; the remaining patients received only EBRT. Seven were lost during follow-up, and seven (21.2%) died during the study period of 6weeks. Nineteen (57.6%) were followed up. On follow-up endoscopy, evidence of residual stricture was observed in 57.9%, and growth in 36.8%. Of the patients, 27.8% had biopsy-confirmed residual disease. The median dysphagia score decreased from 4 to 3 after treatment (p = 0.002) in 17 (89.5%) patients. The mean QoL score improved from 107.5 to 114.1 at 6-week follow-up. Following radiotherapy, 26.3% had persistent chest pain, increased cough with expectoration in 15.8%, and hyperpigmentation of skin in 10.5%. Radiotherapy gives significant relief of dysphagia and improves QoL in 90% of patients with SCC of esophagus. However, following radiotherapy, a number of patients will have persistent stricture, ulceration, and residual disease. Association of Surgeons of India, 2013 Squamous cell carcinoma of esophagus nationallicence Dysphagia score nationallicence Quality of life nationallicence External beam radiotherapy nationallicence Intraluminal brachytherapy nationallicence Prasad N. Department of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, 605006, Puducherry, India aut Karthigeyan M. Department of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, 605006, Puducherry, India aut Vikram Kate Department of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, 605006, Puducherry, India aut Parthasarathy R. Department of Radiotherapy, Jawaharlal Institute of Postgraduate Medical Education and Research, 605006, Puducherry, India aut Reddy K. Department of Radiotherapy, Jawaharlal Institute of Postgraduate Medical Education and Research, 605006, Puducherry, India aut Indian Journal of Surgery Springer India 77/1(2015-02-01), 34-38 0972-2068 77:1<34 2015 77 12262 https://doi.org/10.1007/s12262-013-0817-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12262-013-0817-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Prasad N. Department of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, 605006, Puducherry, India aut NATIONALLICENCE 700 1- Karthigeyan M. Department of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, 605006, Puducherry, India aut NATIONALLICENCE 700 1- Vikram Kate Department of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, 605006, Puducherry, India aut NATIONALLICENCE 700 1- Parthasarathy R. Department of Radiotherapy, Jawaharlal Institute of Postgraduate Medical Education and Research, 605006, Puducherry, India aut NATIONALLICENCE 700 1- Reddy K. Department of Radiotherapy, Jawaharlal Institute of Postgraduate Medical Education and Research, 605006, Puducherry, India aut NATIONALLICENCE 773 0- Indian Journal of Surgery Springer India 77/1(2015-02-01), 34-38 0972-2068 77:1<34 2015 77 12262