caa a22 4500 60624543X CHVBK 20210128101335.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s12262-013-0957-6 doi (NATIONALLICENCE)springer-10.1007/s12262-013-0957-6 Surgical Trauma and Immune Functional Changes Following Major Lung Resection [Elektronische Daten] [Calvin Ng, Kelvin Lau] Video-assisted thoracic surgery (VATS) has evolved greatly over the last two decades. VATS major lung resection for early stage non-small cell lung carcinoma (NSCLC) has been shown to result in less postoperative pain, less pulmonary dysfunction postoperatively, shorter hospital stay, and better patient tolerance to adjuvant chemotherapy compared with patients who underwent thoracotomy. Several recent studies have even reported improved long-term survival in those who underwent VATS major lung resection for early stage NSCLC when compared with open technique. Interestingly, the immune status and autologous tumor killing ability of lung cancer patients have previously been associated with long-term survival. VATS major lung resection can result in an attenuated postoperative inflammatory response. Furthermore, the minimal invasive approach better preserve patients' postoperative immune function, leading to higher circulating natural killer and T cells numbers, T cell oxidative activity, and levels of immunochemokines such as insulin growth factor binding protein 3 following VATS compared with thoracotomy. Apart from host immunity, the angiogenic environment following surgery may also have a role in determining cancer recurrence and possibly survival. Whether differences in immunological and biochemical mediators contribute significantly towards improved clinical outcomes following VATS major lung resection for lung cancer remains to be further investigated. Future studies will also need to address whether the reduced access trauma from advanced thoracic surgical techniques, such as single-port VATS, can further attenuate the postoperative inflammatory response. Association of Surgeons of India, 2013 Angiogenesis nationallicence Immune nationallicence Inflammation nationallicence Single port nationallicence Trauma nationallicence Thoracotomy nationallicence VATS nationallicence Ng Calvin Division of Cardiothoracic Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N.T, Hong Kong, SAR, China aut Lau Kelvin Department of Cardiothoracic Surgery, St Bartholomew's Hospital, West Smithfield, London, UK aut Indian Journal of Surgery Springer India 77/1(2015-02-01), 49-54 0972-2068 77:1<49 2015 77 12262 https://doi.org/10.1007/s12262-013-0957-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12262-013-0957-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ng Calvin Division of Cardiothoracic Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N.T, Hong Kong, SAR, China aut NATIONALLICENCE 700 1- Lau Kelvin Department of Cardiothoracic Surgery, St Bartholomew's Hospital, West Smithfield, London, UK aut NATIONALLICENCE 773 0- Indian Journal of Surgery Springer India 77/1(2015-02-01), 49-54 0972-2068 77:1<49 2015 77 12262