caa a22 4500 606245499 CHVBK 20210128101335.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s12262-015-1300-1 doi (NATIONALLICENCE)springer-10.1007/s12262-015-1300-1 Role of Combined Sentinel Lymph Node Biopsy and Axillary Node Sampling in Clinically Node-Negative Breast Cancer [Elektronische Daten] [K. Edwards, M. Dordea, R. French, V. Kurup] Axillary lymph node status is a prognostic marker in breast cancer management, and axillary surgery plays an important role in staging and local control. This study aims to assess whether a combination of sentinel lymph node biopsy (SLNB) using patent blue dye and axillary node sampling (ANS) offers equivalent identification rate to dual tracer technique. Furthermore, we aim to investigate whether there are any potential benefits to this combined technique. Retrospective study of 230 clinically node-negative patients undergoing breast-conserving surgery for single T1-T3 tumours between 2006 and 2011. Axillae were staged using a combined blue dye SLNB/ANS technique. SLNs were localized in 226/230 (identification rate 98.3%). Three of one hundred ninety-two patients with a negative SLN were found to have positive ANS nodes and 1/4 failed SLNB patients had positive ANS nodes. Thirty-four of two hundred twenty-six patients had SLN metastases and 11/34 (32.4%) also had a positive non-sentinel lymph node on ANS. Twenty-one of twenty-four (87.5%) node-positive T1 tumours had single node involvement. Nine of thirty-eight node-positive patients progressed to completion axillary clearance (cALND), and the rest were treated with axillary radiotherapy. Axillary recurrence was nil at median 5year follow-up. Complementing SLNB with axillary node sampling (ANS) decreases the unavoidable false-negative rate associated with SLNB. Appropriate operator experience and technique can result in an SLN localization rate of 98%, rivalling a dual tracer technique. The additional insight offered by ANS into the status of non-sentinel nodes has potential applications in an era of less frequent cALND. Association of Surgeons of India, 2015 Sentinel lymph node biopsy nationallicence Breast cancer nationallicence Axillary node clearance nationallicence Axillary node sampling nationallicence Edwards K. Breast Unit, North Tees and Hartlepool NHS Foundation Trust, Hardwick Road, TS19 8PE, Stockton-on-Tees, UK aut Dordea M. Breast Unit, North Tees and Hartlepool NHS Foundation Trust, Hardwick Road, TS19 8PE, Stockton-on-Tees, UK aut French R. Breast Unit, North Tees and Hartlepool NHS Foundation Trust, Hardwick Road, TS19 8PE, Stockton-on-Tees, UK aut Kurup V. Breast Unit, North Tees and Hartlepool NHS Foundation Trust, Hardwick Road, TS19 8PE, Stockton-on-Tees, UK aut Indian Journal of Surgery Springer India 77/6(2015-12-01), 495-501 0972-2068 77:6<495 2015 77 12262 https://doi.org/10.1007/s12262-015-1300-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12262-015-1300-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Edwards K. Breast Unit, North Tees and Hartlepool NHS Foundation Trust, Hardwick Road, TS19 8PE, Stockton-on-Tees, UK aut NATIONALLICENCE 700 1- Dordea M. Breast Unit, North Tees and Hartlepool NHS Foundation Trust, Hardwick Road, TS19 8PE, Stockton-on-Tees, UK aut NATIONALLICENCE 700 1- French R. Breast Unit, North Tees and Hartlepool NHS Foundation Trust, Hardwick Road, TS19 8PE, Stockton-on-Tees, UK aut NATIONALLICENCE 700 1- Kurup V. Breast Unit, North Tees and Hartlepool NHS Foundation Trust, Hardwick Road, TS19 8PE, Stockton-on-Tees, UK aut NATIONALLICENCE 773 0- Indian Journal of Surgery Springer India 77/6(2015-12-01), 495-501 0972-2068 77:6<495 2015 77 12262