caa a22 4500 606245537 CHVBK 20210128101336.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s12262-015-1291-y doi (NATIONALLICENCE)springer-10.1007/s12262-015-1291-y Influence of Heparanase and VEGF-C mRNA Expressions in Lung Cancer [Elektronische Daten] [Yongwei Yang, Xiaokaiti Maimaitiyiming, Chengyu Jin, Nuerlan Ahan, Rui Guo, Chuanliang Peng] The objective of this study is to investigate relationship between the expressions of heparanase and vascular endothelial growth factor-C (VEGF-C) mRNA and tumorigenesis, progression in human lung cancer. The expressions of heparanase and VEGF-C mRNA in 65 cases of lung cancer (31 cases of squamous cell carcinoma, 25 adenocarcinoma, 3 large cell carcinoma, and 6 small cell carcinoma), adjacent tissues of cancer, and normal tissues were tested by reverse transcription-polymerase chain reaction (RT-PCR) and analyzed by clinico-pathological characteristics and prognosis of lung cancer. The rate of expressions of heparanase and VEGF-C mRNA in tumor tissues (55.4, 61.5%) was significantly higher than that in adjacent tissues of cancer (12.3, 15.4%) and normal tissues (3.1, 4.6%) (P < 0.05). It was shown that heparanase and VEGF-C mRNA expressions did not correlate with the pathological type and grade of the tumor (P > 0.05), but they correlated with the clinical stage and survival time of the patients (P < 0.05). Overexpression of heparanase and VEGF-C mRNA in lung cancer tissues perhaps participates in regulation of tumorigenesis and progression. The expressions of heparanase and VEGF-C mRNA should be used as a useful marker of the biological behavior of lung cancer and as an independent prognosis factor for the patient's survival. Association of Surgeons of India, 2015 Heparanase nationallicence Vascular endothelial growth factor-C nationallicence mRNA nationallicence Lung cancer nationallicence Yang Yongwei Thoracic Department, Xinjiang Uygur Autonomous Region People's Hospital, Urumqi, China aut Maimaitiyiming Xiaokaiti Thoracic Department, Xinjiang Uygur Autonomous Region People's Hospital, Urumqi, China aut Jin Chengyu Thoracic Department, Xinjiang Uygur Autonomous Region People's Hospital, Urumqi, China aut Ahan Nuerlan Thoracic Department, Xinjiang Uygur Autonomous Region People's Hospital, Urumqi, China aut Guo Rui Thoracic Department, Xinjiang Uygur Autonomous Region People's Hospital, Urumqi, China aut Peng Chuanliang Thoracic Department, The second Hospital of Shandong University, 247, Beiyuan Street, Jinan, China aut Indian Journal of Surgery Springer India 77/6(2015-12-01), 477-480 0972-2068 77:6<477 2015 77 12262 https://doi.org/10.1007/s12262-015-1291-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12262-015-1291-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yang Yongwei Thoracic Department, Xinjiang Uygur Autonomous Region People's Hospital, Urumqi, China aut NATIONALLICENCE 700 1- Maimaitiyiming Xiaokaiti Thoracic Department, Xinjiang Uygur Autonomous Region People's Hospital, Urumqi, China aut NATIONALLICENCE 700 1- Jin Chengyu Thoracic Department, Xinjiang Uygur Autonomous Region People's Hospital, Urumqi, China aut NATIONALLICENCE 700 1- Ahan Nuerlan Thoracic Department, Xinjiang Uygur Autonomous Region People's Hospital, Urumqi, China aut NATIONALLICENCE 700 1- Guo Rui Thoracic Department, Xinjiang Uygur Autonomous Region People's Hospital, Urumqi, China aut NATIONALLICENCE 700 1- Peng Chuanliang Thoracic Department, The second Hospital of Shandong University, 247, Beiyuan Street, Jinan, China aut NATIONALLICENCE 773 0- Indian Journal of Surgery Springer India 77/6(2015-12-01), 477-480 0972-2068 77:6<477 2015 77 12262