caa a22 4500 606245588 CHVBK 20210128101336.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s12262-015-1303-y doi (NATIONALLICENCE)springer-10.1007/s12262-015-1303-y Effect of Curcumin in Experimental Peritonitis [Elektronische Daten] [Savitha D, Indu Mani, Gayatri Ravikumar, Sandhya Avadhany] Despite medical advancements, the inflammatory cascade and oxidative stress worsen the prognosis in most cases of peritonitis. Curcumin has emerged as a potential antioxidant and anti-inflammatory agent in few of the acute inflammatory and infective conditions. We examined the effect of intraperitoneal injection of curcumin in endotoxin-induced peritonitis in rats. The blood and peritoneal fluid samples were collected at 3 and 24h following the induction of peritonitis. Animals were sacrificed at 24h and the organs preserved. The histopathological report of lung, liver, and intestines in the curcumin-treated rats showed maintenance of tissue architecture to a large extent compared to the control group which showed massive congestion, hemorrhage, and necrosis. The blood and peritoneal fluid total count and differential neutrophil counts were significantly higher at 24h of induction of peritonitis. Serum amyloid assay and lipid peroxidation were significantly lower, and myeloperoxidase assay was higher in the curcumin-treated group at the end of 24h; thus, curcumin probably demonstrated a neutrophil-mediated immunopotentiation and anti-inflammatory action thereby protecting the animal from endotoxemia-induced multi-organ damage. Association of Surgeons of India, 2015 Peritonitis nationallicence Curcumin nationallicence Immunopotentiation nationallicence Anti-inflammatory nationallicence D Savitha Department of Physiology, St. John's Medical College, John Nagar, 560034, Bangalore, Karnataka, India aut Mani Indu St Johns Research Institute, Karnataka, India aut Ravikumar Gayatri Department of Pathology, St. John's Medical College, Karnataka, India aut Avadhany Sandhya Department of Physiology, St. John's Medical College, Karnataka, India aut Indian Journal of Surgery Springer India 77/6(2015-12-01), 502-507 0972-2068 77:6<502 2015 77 12262 https://doi.org/10.1007/s12262-015-1303-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12262-015-1303-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- D Savitha Department of Physiology, St. John's Medical College, John Nagar, 560034, Bangalore, Karnataka, India aut NATIONALLICENCE 700 1- Mani Indu St Johns Research Institute, Karnataka, India aut NATIONALLICENCE 700 1- Ravikumar Gayatri Department of Pathology, St. John's Medical College, Karnataka, India aut NATIONALLICENCE 700 1- Avadhany Sandhya Department of Physiology, St. John's Medical College, Karnataka, India aut NATIONALLICENCE 773 0- Indian Journal of Surgery Springer India 77/6(2015-12-01), 502-507 0972-2068 77:6<502 2015 77 12262