caa a22 4500 60624588X CHVBK 20210128101337.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s12262-013-0828-1 doi (NATIONALLICENCE)springer-10.1007/s12262-013-0828-1 In Vivo Healing Effects of Ankaferd Blood Stopper on the Residual Pancreatic Tissue in a Swine Model of Distal Pancreatectomy [Elektronische Daten] [Kerem Karaman, Erdal Bostanci, Bahadir Celep, Nazmiye Dincer, Mevlut Kurt, Zafer Teke, Musa Akoglu, Hasan Bilgili, Sinan Ulusan, Ibrahim Haznedaroglu] The aim of this study was to determine whether intraoperative Ankaferd blood stopper (ABS) application into the pancreatic channel and to the pancreatic remnant surface following distal pancreatectomy can or cannot prevent postoperative pancreatic fistula formation. Three pigs underwent distal pancreatectomy under general anesthesia. In two of the pigs, 0.5ml of ABS was applied to the stump surface area after adding 0.5ml of ABS into the pancreatic channel. The remaining one animal served as the control. The pigs were sacrificed on the seventh postoperative day for autopsy. The pancreatic remnants from the animals were then taken for histopathological analyses. It was observed that the oral intake had been broken and abdominal distention had developed in the control pig following on the third postoperative day. However, no significant clinical changes were observed in the ABS-applied pigs. In the autopsy, it was found that the control pig had generalized peritonitis with pancreatic necrosis. On the other hand, the ABS-applied pigs had either macroscopically and microscopically normal pancreatic tissue architecture with an occluded Wirsung duct at the pancreatic stump. It was concluded that application of ABS on the transected surface and into the pancreatic channel could prevent pancreatic fistula formation and improve wound healing in the residual pancreatic tissue following distal pancreatectomy. Association of Surgeons of India, 2013 Ankaferd blood stopper nationallicence Distal pancreatectomy nationallicence Pancreatic fistula nationallicence Wound healing nationallicence Histopathology nationallicence Amylase nationallicence Karaman Kerem Department of Gastroenterological Surgery, Turkiye Yuksek Ihtisas Teaching and Research Hospital, Ankara, Turkey aut Bostanci Erdal Department of Gastroenterological Surgery, Turkiye Yuksek Ihtisas Teaching and Research Hospital, Ankara, Turkey aut Celep Bahadir Department of Gastroenterological Surgery, Turkiye Yuksek Ihtisas Teaching and Research Hospital, Ankara, Turkey aut Dincer Nazmiye Ataturk Teaching and Research Hospital, Department of Pathology, Ankara, Turkey aut Kurt Mevlut Department of Gastroenterology, Turkiye Yuksek Ihtisas Teaching and Research Hospital, Kızılay Sk. No. 2, Sıhhiye, 06100, Ankara, Turkey aut Teke Zafer Department of Gastroenterological Surgery, Turkiye Yuksek Ihtisas Teaching and Research Hospital, Ankara, Turkey aut Akoglu Musa Department of Gastroenterological Surgery, Turkiye Yuksek Ihtisas Teaching and Research Hospital, Ankara, Turkey aut Bilgili Hasan Department of Surgery, Ankara University, Faculty of Veterinary Medicine, Ankara, Turkey aut Ulusan Sinan Department of Surgery, Ankara University, Faculty of Veterinary Medicine, Ankara, Turkey aut Haznedaroglu Ibrahim Department of Hematology, Hacettepe University, Faculty of Medicine, Ankara, Turkey aut Indian Journal of Surgery Springer India 77/3(2015-06-01), 176-181 0972-2068 77:3<176 2015 77 12262 https://doi.org/10.1007/s12262-013-0828-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12262-013-0828-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Karaman Kerem Department of Gastroenterological Surgery, Turkiye Yuksek Ihtisas Teaching and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Bostanci Erdal Department of Gastroenterological Surgery, Turkiye Yuksek Ihtisas Teaching and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Celep Bahadir Department of Gastroenterological Surgery, Turkiye Yuksek Ihtisas Teaching and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Dincer Nazmiye Ataturk Teaching and Research Hospital, Department of Pathology, Ankara, Turkey aut NATIONALLICENCE 700 1- Kurt Mevlut Department of Gastroenterology, Turkiye Yuksek Ihtisas Teaching and Research Hospital, Kızılay Sk. No. 2, Sıhhiye, 06100, Ankara, Turkey aut NATIONALLICENCE 700 1- Teke Zafer Department of Gastroenterological Surgery, Turkiye Yuksek Ihtisas Teaching and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Akoglu Musa Department of Gastroenterological Surgery, Turkiye Yuksek Ihtisas Teaching and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Bilgili Hasan Department of Surgery, Ankara University, Faculty of Veterinary Medicine, Ankara, Turkey aut NATIONALLICENCE 700 1- Ulusan Sinan Department of Surgery, Ankara University, Faculty of Veterinary Medicine, Ankara, Turkey aut NATIONALLICENCE 700 1- Haznedaroglu Ibrahim Department of Hematology, Hacettepe University, Faculty of Medicine, Ankara, Turkey aut NATIONALLICENCE 773 0- Indian Journal of Surgery Springer India 77/3(2015-06-01), 176-181 0972-2068 77:3<176 2015 77 12262