caa a22 4500 606246606 CHVBK 20210128101341.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s12262-013-0886-4 doi (NATIONALLICENCE)springer-10.1007/s12262-013-0886-4 Regression of Fibroadenomas with Centchroman: a Randomized Controlled Trial [Elektronische Daten] [Prakash Tejwani, Hrishikesh Nerkar, Anita Dhar, Kamal Kataria, Smriti Hari, Sanjay Thulkar, Sunil Chumber, Sunesh Kumar, Anurag Srivastava] Fibroadenoma is a common cause of breast lump in young girls. Nearly 10-15% of lesions regress spontaneously over the period of 6 to 60months. The aim of study was to investigate the role of Centchroman in regression of fibroadenoma in comparison to natural observation and to study the association of hormonal receptors with degree of regression. The study was carried out at the outpatient clinic of Department of Surgery, All India Institute of Medical Sciences, New Delhi, from November 2004 to November 2007. Patients aged ≤30years with fibroadenoma were included. Patients with fibroadenoma equal to or larger than 5cm and with polycystic ovarian disease were excluded. Patients were randomized in two groups. Patients in active therapy arm were prescribed Centchroman 30mg daily for 12weeks, and another group was observed without any intervention (control group). Patients were followed at weeks 4, 8, 12, and 24 to assess response to therapy. Twenty-two (31.88%) fibroadenomas in Centchroman arm disappeared completely as compared to four (7.69%) in control arm over a period of 6months. There was a decrease in the volume of fibroadenoma in ten (19.23%) patients in control arm and 36 (52.17%) patients in Centchroman arm. Centchroman therapy allowed 31% fibroadenoma to regress completely with scanty menses or amenorrhea as the only side effect. Association of Surgeons of India, 2013 Fibroadenoma nationallicence Centchroman nationallicence Polycystic ovarian disease nationallicence Saheli nationallicence Hormone receptor nationallicence Antiestrogen nationallicence Tejwani Prakash SMS Medical College, Jaipur, India aut Nerkar Hrishikesh All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India aut Dhar Anita All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India aut Kataria Kamal All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India aut Hari Smriti All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India aut Thulkar Sanjay All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India aut Chumber Sunil All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India aut Kumar Sunesh All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India aut Srivastava Anurag Department of Surgical Disciplines, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India aut Indian Journal of Surgery Springer India 77(2015-12-01), 484-489 0972-2068 77<484 2015 77 12262 https://doi.org/10.1007/s12262-013-0886-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12262-013-0886-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tejwani Prakash SMS Medical College, Jaipur, India aut NATIONALLICENCE 700 1- Nerkar Hrishikesh All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India aut NATIONALLICENCE 700 1- Dhar Anita All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India aut NATIONALLICENCE 700 1- Kataria Kamal All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India aut NATIONALLICENCE 700 1- Hari Smriti All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India aut NATIONALLICENCE 700 1- Thulkar Sanjay All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India aut NATIONALLICENCE 700 1- Chumber Sunil All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India aut NATIONALLICENCE 700 1- Kumar Sunesh All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India aut NATIONALLICENCE 700 1- Srivastava Anurag Department of Surgical Disciplines, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India aut NATIONALLICENCE 773 0- Indian Journal of Surgery Springer India 77(2015-12-01), 484-489 0972-2068 77<484 2015 77 12262