caa a22 4500 606246622 CHVBK 20210128101341.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s12262-013-0875-7 doi (NATIONALLICENCE)springer-10.1007/s12262-013-0875-7 Use of Amnion Transfer in Resistant Nonhealing Venous Leg Ulcers [Elektronische Daten] [Joseph Francis, C. Shajimon, A. Bhat, B. Kanakambaran] In the treatment of venous leg ulcers, after adopting many treatment modalities, at times we are still left with a local indolent problem, "the resistant nonhealing venous ulcer.” With repeated surgical procedures failing to obtain a healed ulcer, constant pain, persistent discharging wound, infections, etc., many a patient turn hostile. Also, there comes a dimension of despair in the health feeling of the patient. This prospective study was conducted in 40 patients, who were within the inclusion criteria (January 2006-January 2010, 12 males and 28 females, mean age 45years). A single amniotic membrane (AM) transfer was done after preparation of the wound, and the parameters were assessed periodically. Follow-up for a minimum period of 1year in all cases and a maximum period of 3years in many cases (38) was done. Significant clinical response was defined as an ulcer healing greater than 75% of the original area. Treatment failure was taken as a persistence or recurrence of more than 25% of the ulcer area in a 1-year follow-up period. The preliminary results of good ulcer healing and no recurrence are encouraging, even up to 3-year follow-up. This proof-of-concept study demonstrates that AM transfer is useful, safe, inexpensive, readily available, and well accepted by patients, with tremendous potential in promoting epithelial healing in "the resistant nonhealing chronic venous leg ulcer.” Association of Surgeons of India, 2013 Resistant nonhealing venous ulcers nationallicence AM transfer nationallicence Epithelization nationallicence Wound infection nationallicence Healing nationallicence Recurrence nationallicence Francis Joseph Department of Surgery, Co-operative Medical College, HMT P.O., Kalamassery, 683503, Kochi, India aut Shajimon C. Department of Surgery, Co-operative Medical College, HMT P.O., Kalamassery, 683503, Kochi, India aut Bhat A. Department of Surgery, Co-operative Medical College, HMT P.O., Kalamassery, 683503, Kochi, India aut Kanakambaran B. Department of Surgery, Co-operative Medical College, HMT P.O., Kalamassery, 683503, Kochi, India aut Indian Journal of Surgery Springer India 77(2015-12-01), 457-462 0972-2068 77<457 2015 77 12262 https://doi.org/10.1007/s12262-013-0875-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12262-013-0875-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Francis Joseph Department of Surgery, Co-operative Medical College, HMT P.O., Kalamassery, 683503, Kochi, India aut NATIONALLICENCE 700 1- Shajimon C. Department of Surgery, Co-operative Medical College, HMT P.O., Kalamassery, 683503, Kochi, India aut NATIONALLICENCE 700 1- Bhat A. Department of Surgery, Co-operative Medical College, HMT P.O., Kalamassery, 683503, Kochi, India aut NATIONALLICENCE 700 1- Kanakambaran B. Department of Surgery, Co-operative Medical College, HMT P.O., Kalamassery, 683503, Kochi, India aut NATIONALLICENCE 773 0- Indian Journal of Surgery Springer India 77(2015-12-01), 457-462 0972-2068 77<457 2015 77 12262