caa a22 4500 60624672X CHVBK 20210128101341.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s12262-013-0871-y doi (NATIONALLICENCE)springer-10.1007/s12262-013-0871-y HER2 Expression in Gastric and Gastroesophageal Cancer: Report from a Tertiary Care Hospital in North India [Elektronische Daten] [Mallika Tewari, Akhileshwar Kumar, RR Mishra, Mohan Kumar, Hari Shukla] Despite improvements in chemotherapy, survival of metastatic gastric and gastroesophageal junction (GEJ) adenocarcinoma remains poor. Trastuzumab, a monoclonal antibody targeting the human epidermal growth factor receptor 2 (HER2), has shown promise in improving survival of these patients by a recent large phase III trial. HER2 status in gastric and GEJ cancers, although reported from across the world, is yet unknown in India due to lack of published literature from the country. HER2 status in 70 samples of gastric and GEJ adenocarcinomas (Siewert type III) was evaluated by immunohistochemistry (IHC) in this study using the gastric cancer scoring system. It was also correlated with clinic-pathologic factors. Samples with IHC score 2+ and 3+ were taken as HER2 positive. HER2 overexpression was found in 15 (21.4%) samples, was significantly (p = 0.006) more common in intestinal type (45%), but it did not correlate with age, gender, stage, or grade of tumor and did not affect the 2-year disease-free survival. HER2 overexpression is found only in a minority of patients with gastric and GEJ cancers in the Indian population. A large cohort of patients with a longer follow-up will be required to assess for any significant statistical association of HER2 expression with prognosis of these patients. Association of Surgeons of India, 2013 Gastric cancer nationallicence Gastroesophageal cancer nationallicence HER2 expression nationallicence Tewari Mallika Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, 7 SKG Colony, Lanka, 221005, Varanasi, Uttar Pradesh, India aut Kumar Akhileshwar Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, 7 SKG Colony, Lanka, 221005, Varanasi, Uttar Pradesh, India aut Mishra RR Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, 7 SKG Colony, Lanka, 221005, Varanasi, Uttar Pradesh, India aut Kumar Mohan Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India aut Shukla Hari Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, 7 SKG Colony, Lanka, 221005, Varanasi, Uttar Pradesh, India aut Indian Journal of Surgery Springer India 77(2015-12-01), 447-451 0972-2068 77<447 2015 77 12262 https://doi.org/10.1007/s12262-013-0871-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12262-013-0871-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tewari Mallika Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, 7 SKG Colony, Lanka, 221005, Varanasi, Uttar Pradesh, India aut NATIONALLICENCE 700 1- Kumar Akhileshwar Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, 7 SKG Colony, Lanka, 221005, Varanasi, Uttar Pradesh, India aut NATIONALLICENCE 700 1- Mishra RR Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, 7 SKG Colony, Lanka, 221005, Varanasi, Uttar Pradesh, India aut NATIONALLICENCE 700 1- Kumar Mohan Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India aut NATIONALLICENCE 700 1- Shukla Hari Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, 7 SKG Colony, Lanka, 221005, Varanasi, Uttar Pradesh, India aut NATIONALLICENCE 773 0- Indian Journal of Surgery Springer India 77(2015-12-01), 447-451 0972-2068 77<447 2015 77 12262