caa a22 4500 606246738 CHVBK 20210128101341.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s12262-013-0854-z doi (NATIONALLICENCE)springer-10.1007/s12262-013-0854-z The Effectiveness of Porcine Dermal Collagen (Permacol®) on Wound Healing in the Rat Model [Elektronische Daten] [Murat Kalin, Serdar Kuru, Kemal Kismet, Aziz Barlas, Yusuf Akgun, Hesna Astarci, Huseyin Ustun, Ertugrul Ertas] Porcine acellular dermal collagen (PDC), which is a biological material derived from processing porcine dermis, has already been used for urologic, gynecologic, plastic, and general surgery procedures up to now. The aim of this study is to investigate the effectiveness of PDC on wound healing as a dermal substitute in the rat model. Twenty Wistar albino rats were divided into two groups. Standard full-thickness skin defects were created on the back of the rats. In the control group (Group 1), the dressings moisturized with saline were changed daily. In the study group (Group 2), porcine dermal collagen was implanted onto each wound and fixed with 4-0 polypropylene sutures. Contraction percentages of wound areas were calculated on the third, seventh, tenth, and fourteenth days by using the planimetric program. On fourteenth day, the wound areas were excised for histopathological examination, inflammatory scoring, and evaluation of collagen deposition. The study group was superior to the control group in terms of inflammatory scoring, type I/type III collagen ratio, and wound contraction rates. Porcine dermal collagen may be used effectively and safely on full-thickness wounds as a current dermal substitute. Association of Surgeons of India, 2013 Porcine dermal collagen nationallicence Natural biological materials nationallicence Dermal substitutes nationallicence Wound healing nationallicence Kalin Murat General Surgery Department, Ankara Training and Research Hospital, Ankara, Turkey aut Kuru Serdar General Surgery Department, Ankara Training and Research Hospital, Ankara, Turkey aut Kismet Kemal General Surgery Department, Ankara Training and Research Hospital, Ankara, Turkey aut Barlas Aziz General Surgery Department, Ankara Training and Research Hospital, Ankara, Turkey aut Akgun Yusuf General Surgery Department, Ankara Training and Research Hospital, Ankara, Turkey aut Astarci Hesna Pathology Department, Ankara Training and Research Hospital, Ankara, Turkey aut Ustun Huseyin Pathology Department, Ankara Training and Research Hospital, Ankara, Turkey aut Ertas Ertugrul General Surgery Department, Ankara Training and Research Hospital, Ankara, Turkey aut Indian Journal of Surgery Springer India 77(2015-12-01), 407-411 0972-2068 77<407 2015 77 12262 https://doi.org/10.1007/s12262-013-0854-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12262-013-0854-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kalin Murat General Surgery Department, Ankara Training and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Kuru Serdar General Surgery Department, Ankara Training and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Kismet Kemal General Surgery Department, Ankara Training and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Barlas Aziz General Surgery Department, Ankara Training and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Akgun Yusuf General Surgery Department, Ankara Training and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Astarci Hesna Pathology Department, Ankara Training and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Ustun Huseyin Pathology Department, Ankara Training and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Ertas Ertugrul General Surgery Department, Ankara Training and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 773 0- Indian Journal of Surgery Springer India 77(2015-12-01), 407-411 0972-2068 77<407 2015 77 12262