caa a22 4500 606246800 CHVBK 20210128101342.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s12262-013-0919-z doi (NATIONALLICENCE)springer-10.1007/s12262-013-0919-z Osteopontin Expression in Patients with Hepatolith [Elektronische Daten] [Bum Kim, Sun Joo, Sung Lim, Kwang Joo] To investigate the role of osteopontin (OPN) in the formation of hepatolith, we have immunohistochemically studied the involvement of OPN in hepatolithiasis in the intrahepatic bile ducts and the intramural and extramural glands, and in stones. In our hospital, 17 hepatic resections for hepatolithiasis were carried out from June 2006 to October 2009. Immunohistochemistry was performed on 17 liver specimens with hepatolith and on 24 control liver specimens without hepatolith. We compared the osetopontin expression in the epithelia of the intrahepatic bile ducts and peribiliary glands or periglandular macrophages. Staining for OPN was positive in the cytoplasm of the epithelial cells of stone-containing intrahepatic bile ducts and the intramural and extramural glands, and in stones. But there were no significant differences between the hepatolithiasis group and the control group for the OPN immunoreactivity of the luminal surface of the epithelial cells of the intrahepatic bile ducts and intramural and extramural glands. The stone-containing intrahepatic bile ducts were infiltrated by macrophages that showed intense staining for OPN. The core and matrix of the stones showed OPN immunoreactivity. The degree of OPN from the cytoplasm of the epithelia of the intrahepatic bile ducts and peribiliary glands or periglandular macrophages was different between hepatolithiasis and control groups. Our result suggests that the OPN from the intrahepatic bile ducts and peribiliary glands plays a role in the formation of intrahepatic stone. Association of Surgeons of India, 2013 Osteopontin nationallicence Hepatolithiasis nationallicence Intrahepatic bile duct nationallicence Immunohistochemistry nationallicence Kim Bum Department of Surgery, School of Medicine, Kyung Hee University, Seoul, Korea aut Joo Sun Department of Surgery, School of Medicine, Kyung Hee University, Seoul, Korea aut Lim Sung Department of Pathology, School of Medicine, Kyung Hee University, Seoul, Korea aut Joo Kwang Department of Internal Medicine, School of Medicine, Kyung Hee University, Seoul, Korea aut Indian Journal of Surgery Springer India 77(2015-12-01), 551-556 0972-2068 77<551 2015 77 12262 https://doi.org/10.1007/s12262-013-0919-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12262-013-0919-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim Bum Department of Surgery, School of Medicine, Kyung Hee University, Seoul, Korea aut NATIONALLICENCE 700 1- Joo Sun Department of Surgery, School of Medicine, Kyung Hee University, Seoul, Korea aut NATIONALLICENCE 700 1- Lim Sung Department of Pathology, School of Medicine, Kyung Hee University, Seoul, Korea aut NATIONALLICENCE 700 1- Joo Kwang Department of Internal Medicine, School of Medicine, Kyung Hee University, Seoul, Korea aut NATIONALLICENCE 773 0- Indian Journal of Surgery Springer India 77(2015-12-01), 551-556 0972-2068 77<551 2015 77 12262