caa a22 4500 606246819 CHVBK 20210128101342.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s12262-013-0844-1 doi (NATIONALLICENCE)springer-10.1007/s12262-013-0844-1 Does Rigid Cystoscopy Affect the Total Serum Prostate-Specific Antigen Levels? [Elektronische Daten] [Iqbal Singh, Ravi Prasad, Vivek Agarwal, R Tripathi] In the present study, we aim to prospectively evaluate the effect of performing rigid cystoscopy (CPE) in urological patients on the total serum prostate-specific antigen (PSA) levels. The study design was a prospective observational study. After giving informed consent, urological patients visiting the outpatient clinic of our institution from November 2010 to March 2012 who satisfied our protocol entry/exclusion criteria were recruited into the present study. Blood sample was withdrawn 1h prior to CPE for serum PSA estimation, and CPE was performed with a 17-Fr rigid cystoscope. Blood was again withdrawn at 1 and 24h after CPE for serum PSA estimation. The study used paired samples test (two tailed) for statistical analysis. A total of 50 patients with mean age of 60years underwent CPE. The baseline, 1-h, and 24-h post CPE mean serum PSA levels were 1.98 ± 2.25 (0.02-12.33), 2.90 ± 2.81 (0.3-14.26), and 3.04 ± 2.95 (0.2-15.03) ng/dl, respectively. The paired samples test (two tailed) revealed that the rise in the baseline PSA versus 1-h PSA and baseline PSA versus 24-h PSA was highly significant at P < 0.001 and P < 0.002, respectively; however, the 1-h PSA versus 24-h PSA rise was not so significant (P < 0.043). The present study demonstrated that rigid cystoscopy may be associated with a variable rise in the serum PSA that may persist for a period of up to or beyond 24h. Thus, we believe that the history of recent cystoscopy must be taken into consideration while interpreting the serum PSA value in the routine urological setting, as this will reduce unnecessary prostate biopsies in patients with an elevated serum PSA. Therefore, it may be advisable to wait for 24-48h before withdrawing blood for serum PSA estimation in patients with history of CPE in the previous 24-48h. Association of Surgeons of India, 2013 Prostate-specific antigen nationallicence Cystoscopy nationallicence Check cystoscopy nationallicence Singh Iqbal Department of Surgery (Urology Division), University College of Medical Sciences (University of Delhi) and GTB Hospital, 110095, Delhi, India aut Prasad Ravi Department of Surgery (Urology Division), University College of Medical Sciences (University of Delhi) and GTB Hospital, 110095, Delhi, India aut Agarwal Vivek Department of Surgery, University College of Medical Sciences (University of Delhi) and GTB Hospital, 110095, Delhi, India aut Tripathi R. Department of Surgery, University College of Medical Sciences (University of Delhi) and GTB Hospital, 110095, Delhi, India aut Indian Journal of Surgery Springer India 77(2015-12-01), 365-369 0972-2068 77<365 2015 77 12262 https://doi.org/10.1007/s12262-013-0844-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12262-013-0844-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Singh Iqbal Department of Surgery (Urology Division), University College of Medical Sciences (University of Delhi) and GTB Hospital, 110095, Delhi, India aut NATIONALLICENCE 700 1- Prasad Ravi Department of Surgery (Urology Division), University College of Medical Sciences (University of Delhi) and GTB Hospital, 110095, Delhi, India aut NATIONALLICENCE 700 1- Agarwal Vivek Department of Surgery, University College of Medical Sciences (University of Delhi) and GTB Hospital, 110095, Delhi, India aut NATIONALLICENCE 700 1- Tripathi R. Department of Surgery, University College of Medical Sciences (University of Delhi) and GTB Hospital, 110095, Delhi, India aut NATIONALLICENCE 773 0- Indian Journal of Surgery Springer India 77(2015-12-01), 365-369 0972-2068 77<365 2015 77 12262