caa a22 4500 606247130 CHVBK 20210128101343.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s12262-013-0928-y doi (NATIONALLICENCE)springer-10.1007/s12262-013-0928-y Cytological Study of Breast Carcinoma Before and After Oncotherapy with Special Reference to Morphometry and Proliferative Activity [Elektronische Daten] [Sananda Koley, Srabani Chakrabarti, Swapan Pathak, Asim Manna, Siddhartha Basu] Our study was done to assess the cytological changes due to oncotherapy in breast carcinoma especially on morphometry and proliferative activity. Cytological aspirates were collected from a total of 32 cases of invasive ductal carcinoma both before and after oncotherapy. Morphometry was done on the stained cytological smears to assess the different morphological parameters of cell dimension by using the ocular morphometer and the software AutoCAD 2007. Staining was done with Ki-67 and proliferating cell nuclear antigen (PCNA) as proliferative markers. Different morphological parameters were compared before and after oncotherapy by unpaired Student's t test. Statistically significant differences were found in morphometric parameters, e.g., mean nuclear diameter, mean nuclear area, mean cell diameter, and mean cell area, and in the expression of proliferative markers (Ki-67 and PCNA). Statistical analysis was done by obtaining p values. There are statistically significant differences between morphological parameter of breast carcinoma cells before and after oncotherapy. Association of Surgeons of India, 2013 Breast carcinoma nationallicence Oncotherapy nationallicence Morphometry nationallicence Proliferative activity nationallicence TDLU : Terminal duct lobular unit nationallicence MRI : Magnetic resonance imaging nationallicence FNAC : Fine needle aspiration cytology nationallicence PCNA : Proliferating cell nuclear antigen nationallicence H&E : Hematoxylin and eosin nationallicence PAP : Papanicolaou nationallicence MGG : May-Grunwald Giemsa nationallicence MND : Mean nuclear diameter nationallicence MNA : Mean nuclear area nationallicence MCD : Mean cell diameter nationallicence MCA : Mean cell area nationallicence N:C ratio : Nucleocytoplasmic ratio nationallicence pCR : Pathological complete remission nationallicence Koley Sananda Department of Pathology, IPGMER, Kolkata, West Bengal, India aut Chakrabarti Srabani Department of Pathology, BSMC&H, Bankura, West Bengal, India aut Pathak Swapan Department of Pathology, BSMC&H, Bankura, West Bengal, India aut Manna Asim Department of Pathology, IPGMER, Kolkata, West Bengal, India aut Basu Siddhartha Department of Radiotherapy, IPGMER, 244 AJC Bose Road, 700020, Kolkata, West Bengal, India aut Indian Journal of Surgery Springer India 77(2015-12-01), 570-575 0972-2068 77<570 2015 77 12262 https://doi.org/10.1007/s12262-013-0928-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12262-013-0928-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Koley Sananda Department of Pathology, IPGMER, Kolkata, West Bengal, India aut NATIONALLICENCE 700 1- Chakrabarti Srabani Department of Pathology, BSMC&H, Bankura, West Bengal, India aut NATIONALLICENCE 700 1- Pathak Swapan Department of Pathology, BSMC&H, Bankura, West Bengal, India aut NATIONALLICENCE 700 1- Manna Asim Department of Pathology, IPGMER, Kolkata, West Bengal, India aut NATIONALLICENCE 700 1- Basu Siddhartha Department of Radiotherapy, IPGMER, 244 AJC Bose Road, 700020, Kolkata, West Bengal, India aut NATIONALLICENCE 773 0- Indian Journal of Surgery Springer India 77(2015-12-01), 570-575 0972-2068 77<570 2015 77 12262