caa a22 4500 606247246 CHVBK 20210128101344.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s12262-013-0896-2 doi (NATIONALLICENCE)springer-10.1007/s12262-013-0896-2 Myofibroblastoma of the Breast: Diagnostic Challenges of a Rare Benign Tumor [Elektronische Daten] [Aikaterini Kazani, Aikaterini Mastoraki, Christina Dastamani, Vaia Stafyla, Evangelia Kairi, Ioannis Psychogios, Nikolaos Arkadopoulos] Breast myofibroblastomas (MFBs) are rare benign tumors that have recently been recognized as a distinct entity. They are more common in men and often coexist with gynecomastia. Fine needle aspiration cytology or core biopsy should always be performed for triple assessment; however, due to the multiple variants of the tumor, final diagnosis can be safely accomplished only postoperatively with the aid of immunohistochemistry. The main histological characteristic that differentiates MFBs from the majority of malignant mesenchymal breast lesions is the presence of spindle cells in a collagenous background. Low mitotic activity and vimentin and CD34 positivity have been reported as well. Surgical excision retains a pivotal diagnostic and curative role. Local resection is sufficient, but mastectomy can also be advocated either in cases of male patients with coexisting gynecomastia or in females with large tumors. Into this retrospective survey, three cases of breast MFB were consecutively enrolled. Two patients were postmenopausal females and one was male. Relevant literature is briefly reviewed. Clinical features, histogenesis, morphological, and immunochemical findings are discussed, while the role of the current diagnostic and therapeutic management of this uncommon neoplasm is emphasized. Association of Surgeons of India, 2013 Myofibroblastoma nationallicence Breast lesions nationallicence Benign spindle stromal tumors nationallicence Kazani Aikaterini 4th Department of Surgery, ATTIKON University Hospital, GR-115 26, Athens, Greece aut Mastoraki Aikaterini 4th Department of Surgery, ATTIKON University Hospital, GR-115 26, Athens, Greece aut Dastamani Christina 4th Department of Surgery, ATTIKON University Hospital, GR-115 26, Athens, Greece aut Stafyla Vaia 4th Department of Surgery, ATTIKON University Hospital, GR-115 26, Athens, Greece aut Kairi Evangelia 4th Department of Surgery, ATTIKON University Hospital, GR-115 26, Athens, Greece aut Psychogios Ioannis 4th Department of Surgery, ATTIKON University Hospital, GR-115 26, Athens, Greece aut Arkadopoulos Nikolaos 4th Department of Surgery, ATTIKON University Hospital, GR-115 26, Athens, Greece aut Indian Journal of Surgery Springer India 77(2015-12-01), 501-504 0972-2068 77<501 2015 77 12262 https://doi.org/10.1007/s12262-013-0896-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12262-013-0896-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kazani Aikaterini 4th Department of Surgery, ATTIKON University Hospital, GR-115 26, Athens, Greece aut NATIONALLICENCE 700 1- Mastoraki Aikaterini 4th Department of Surgery, ATTIKON University Hospital, GR-115 26, Athens, Greece aut NATIONALLICENCE 700 1- Dastamani Christina 4th Department of Surgery, ATTIKON University Hospital, GR-115 26, Athens, Greece aut NATIONALLICENCE 700 1- Stafyla Vaia 4th Department of Surgery, ATTIKON University Hospital, GR-115 26, Athens, Greece aut NATIONALLICENCE 700 1- Kairi Evangelia 4th Department of Surgery, ATTIKON University Hospital, GR-115 26, Athens, Greece aut NATIONALLICENCE 700 1- Psychogios Ioannis 4th Department of Surgery, ATTIKON University Hospital, GR-115 26, Athens, Greece aut NATIONALLICENCE 700 1- Arkadopoulos Nikolaos 4th Department of Surgery, ATTIKON University Hospital, GR-115 26, Athens, Greece aut NATIONALLICENCE 773 0- Indian Journal of Surgery Springer India 77(2015-12-01), 501-504 0972-2068 77<501 2015 77 12262