caa a22 4500 606247297 CHVBK 20210128101344.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s12262-013-0949-6 doi (NATIONALLICENCE)springer-10.1007/s12262-013-0949-6 A Randomized, Controlled Trial to Assess the Efficacy of Arthroscopic Debridement in Combination with Oral Medication Versus Oral Medication in Patients with Gouty Knee Arthritis [Elektronische Daten] [Xin Wang, Pingping Wanyan, Jian Wang, Jin Tian, Long Hu, Xi Shen, Ke Yang] Gouty knee arthritis refers to a form of inflammatory diseases caused by deposits of needle-like crystals of uric acid in knee joint. The aim of this study was to assess the efficacy and safety of arthroscopic debridement in combination with oral medication versus oral medication alone for the treatment of gouty knee arthritis. A total of 60 patients with gouty knee arthritis were randomized to receive either arthroscopic surgery in combination with oral medication or oral medication alone. Efficacy was assessed with the angle of motion, functions, and visual analog scale (VAS). These indices were measured prior to treatment and at 2, 4, 12, 24, and 48weeks posttreatment. Surgery- and medication-related complications were observed. Significant differences in flexion and extension of the knee joint, lymphoma scores, and VAS were detected between the two groups at 2, 4, and 12weeks posttreatment (P < 0.05) but not at weeks 24 and 48 posttreatment (P > 0.05) . Significant differences in these indices were detected at different time points in each group (P < 0.05), except between weeks 24 and 48 (P > 0.05). Arthroscopic surgery in combination with oral medication is superior to single oral medication in the flexion and extension of the knee joint, lymphoma scores, and pain relief (VAS) before 24weeks, although no statistical differences were detected in the efficacy after 24weeks, and in medication-related safety between the two groups. Although arthroscopic debridement cannot replace systemic uric acid-lowering treatments such as medication and dietary control, it is still an effective approach. Association of Surgeons of India, 2013 Randomized controlled trial nationallicence Gouty knee arthritis nationallicence Arthroscopic debridement nationallicence Wang Xin First Clinical Medical College of Lanzhou University, the First Hospital of Lanzhou University, Dong Gang West Road, No. 199, 730000, Lanzhou, Gansu, China aut Wanyan Pingping The Second Hospital of Lanzhou University, Cui Ying Men, 730030, Lanzhou, Gansu, China aut Wang Jian The First Hospital of Lanzhou University, Dong Gang West Road, No. 199, 730000, Lanzhou, Gansu, China aut Tian Jin Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Dong Gang West Road, No. 199, 730000, Lanzhou, Gansu, China aut Hu Long Orthopedics Department, The First Hospital of Lanzhou University, Lanzhou, Gansu, China aut Shen Xi Department of Epidemiology and Health Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu, China aut Yang Ke Evidence-Based Medicine Center, The First Clinical Medical College of Lanzhou University, Dong Gang West Road, No. 199, 730000, Lanzhou, Gansu, China aut Indian Journal of Surgery Springer India 77(2015-12-01), 628-634 0972-2068 77<628 2015 77 12262 https://doi.org/10.1007/s12262-013-0949-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12262-013-0949-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Xin First Clinical Medical College of Lanzhou University, the First Hospital of Lanzhou University, Dong Gang West Road, No. 199, 730000, Lanzhou, Gansu, China aut NATIONALLICENCE 700 1- Wanyan Pingping The Second Hospital of Lanzhou University, Cui Ying Men, 730030, Lanzhou, Gansu, China aut NATIONALLICENCE 700 1- Wang Jian The First Hospital of Lanzhou University, Dong Gang West Road, No. 199, 730000, Lanzhou, Gansu, China aut NATIONALLICENCE 700 1- Tian Jin Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Dong Gang West Road, No. 199, 730000, Lanzhou, Gansu, China aut NATIONALLICENCE 700 1- Hu Long Orthopedics Department, The First Hospital of Lanzhou University, Lanzhou, Gansu, China aut NATIONALLICENCE 700 1- Shen Xi Department of Epidemiology and Health Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu, China aut NATIONALLICENCE 700 1- Yang Ke Evidence-Based Medicine Center, The First Clinical Medical College of Lanzhou University, Dong Gang West Road, No. 199, 730000, Lanzhou, Gansu, China aut NATIONALLICENCE 773 0- Indian Journal of Surgery Springer India 77(2015-12-01), 628-634 0972-2068 77<628 2015 77 12262