caa a22 4500 606247327 CHVBK 20210128101344.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s12262-013-0827-2 doi (NATIONALLICENCE)springer-10.1007/s12262-013-0827-2 Intraoperative Frozen Section Evaluation of Sentinel Lymph Nodes in Breast Carcinoma: Single-Institution Indian Experience [Elektronische Daten] [S. Somashekhar, Zahoor Naikoo, Shabber Zaveri, Soumya Holla, Suresh Chandra, Suniti Mishra, R. Parameswaran] Sentinel lymph node biopsy is an established way of predicting axillary nodal metastasis in early breast cancer. Intraoperative frozen sections (FS) of sentinel lymph nodes (SLNs) can be used to detect metastatic disease, allowing immediate axillary lymph node dissection. The purpose of this study was to evaluate the accuracy of intraoperative frozen sections in evaluation of sentinel lymph nodes in cases of breast cancer. Between March 2006 and August 2010, a total of 164 patients with clinically node-negative operable breast cancer were subjected to sentinel lymph node biopsy of axillary lymph nodes using preoperative peritumoral injection of radioactive colloid and methylene blue. Intraoperative identification of sentinel nodes was done using a handheld gamma probe and identification of blue-stained nodes. The nodes were sent for frozen section examination. The results of frozen section were compared with the final histopathology. Out of the 164 cases, metastases were detected in SLN by frozen section in 38 cases. There were three false-negative cases (all showing micrometastasis on final histopathology). FS had sensitivity of 92.6%, specificity of 100%, and overall accuracy of 98.1%. The positive predictive value was 100%, and the negative predictive value was 97.6%. FS for diagnosis of metastasis of SLNs is reliable. Patients with negative SLNs by the FS diagnosis can avoid reoperation for axillary lymph node dissection. However, FS may fail to detect micrometastases, especially in cases with small tumors. Association of Surgeons of India, 2013 Breast cancer nationallicence Frozen section nationallicence Sentinel node nationallicence Axillary clearance nationallicence Somashekhar S. Dept. of Surgical Oncology, Manipal Comprehensive Cancer Centre, Manipal Hospital, # 98, HAL Airport road, Bangalore, India aut Naikoo Zahoor Dept. of Surgical Oncology, Manipal Comprehensive Cancer Centre, Manipal Hospital, # 98, HAL Airport road, Bangalore, India aut Zaveri Shabber Dept. of Surgical Oncology, Manipal Comprehensive Cancer Centre, Manipal Hospital, # 98, HAL Airport road, Bangalore, India aut Holla Soumya Dept. of Surgical Oncology, Manipal Comprehensive Cancer Centre, Manipal Hospital, # 98, HAL Airport road, Bangalore, India aut Chandra Suresh Department of Pathology, Manipal Hospital, # 98, HAL Airport road, Bangalore, India aut Mishra Suniti Department of Pathology, Manipal Hospital, # 98, HAL Airport road, Bangalore, India aut Parameswaran R. Department of Nuclear Medicine, Manipal Hospital, # 98, HAL Airport road, Bangalore, India aut Indian Journal of Surgery Springer India 77(2015-12-01), 335-340 0972-2068 77<335 2015 77 12262 https://doi.org/10.1007/s12262-013-0827-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12262-013-0827-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Somashekhar S. Dept. of Surgical Oncology, Manipal Comprehensive Cancer Centre, Manipal Hospital, # 98, HAL Airport road, Bangalore, India aut NATIONALLICENCE 700 1- Naikoo Zahoor Dept. of Surgical Oncology, Manipal Comprehensive Cancer Centre, Manipal Hospital, # 98, HAL Airport road, Bangalore, India aut NATIONALLICENCE 700 1- Zaveri Shabber Dept. of Surgical Oncology, Manipal Comprehensive Cancer Centre, Manipal Hospital, # 98, HAL Airport road, Bangalore, India aut NATIONALLICENCE 700 1- Holla Soumya Dept. of Surgical Oncology, Manipal Comprehensive Cancer Centre, Manipal Hospital, # 98, HAL Airport road, Bangalore, India aut NATIONALLICENCE 700 1- Chandra Suresh Department of Pathology, Manipal Hospital, # 98, HAL Airport road, Bangalore, India aut NATIONALLICENCE 700 1- Mishra Suniti Department of Pathology, Manipal Hospital, # 98, HAL Airport road, Bangalore, India aut NATIONALLICENCE 700 1- Parameswaran R. Department of Nuclear Medicine, Manipal Hospital, # 98, HAL Airport road, Bangalore, India aut NATIONALLICENCE 773 0- Indian Journal of Surgery Springer India 77(2015-12-01), 335-340 0972-2068 77<335 2015 77 12262