caa a22 4500 606247343 CHVBK 20210128101344.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s12262-013-0921-5 doi (NATIONALLICENCE)springer-10.1007/s12262-013-0921-5 Hematological, Biochemical, and Immunological Laboratory and Histomorphological Effects of Sleeve Gastrectomy on Female Rats [Elektronische Daten] [Ali Aktekin, Kazım Kazan, Pembegul Gunes, Murat Yekrek, Tolga Muftuoglu, Abdullah Saglam] Restriction of food intake leads to immunologic and histomorphological changes in rats demonstrated by Moriyama. This study is planned to show how sleeve gastrectomy restricts food intake and its effects on biochemical liver function, immunologic and hematologic laboratory parameters, and histomorphological changes in rats. We used sleeve gastrectomy model on seven young adult female rats and compared study group with sham and control groups. Food consumption of rats was measured. All rats were sacrificed on the 50th day, and blood and tissue samples were collected. There was a significant low food intake in sleeve gastrectomy group (p = 0.013). No differences were observed on hematologic, biochemical, and immunologic laboratory parameters between groups. Toxicity parameters in liver samples such as cytoplasmic atrophy, single-cell hepatocellular necrosis, and necrotic eosinophilic cells were significantly high in sleeve gastrectomy group (p = 0.005). Histomorphological examination of the spleen and kidneys revealed significant changes in sleeve gastrectomy and sham groups compared with controls (p = 0.004 and p = 0.018, respectively). Although sleeve gastrectomy does not lead to alteration in hematologic, biochemical, and immunologic laboratory parameters, it causes decreased food consumption, which results in toxicological histomorphological changes in rat liver as well as some changes in kidney and spleen samples. Association of Surgeons of India, 2013 Bariatric surgery nationallicence Obesity nationallicence Gastrectomy nationallicence Rat nationallicence SG : Sleeve gastrectomy nationallicence WBC : Total leukocyte nationallicence AST : Aspartate aminotransferase nationallicence ALT : Alanine aminotransferase nationallicence OGTT : Oral glucose tolerance test nationallicence ITT : Insulin tolerance test nationallicence Aktekin Ali 4th General Surgery Clinic, Haydarpasa Numune Training and Research Hospital, 17 Selimiye Uskudar, 34668, Istanbul, Turkey aut Kazan Kazım 4th General Surgery Clinic, Haydarpasa Numune Training and Research Hospital, 17 Selimiye Uskudar, 34668, Istanbul, Turkey aut Gunes Pembegul Pathology Section, Haydarpasa Numune Training and Research Hospital, 17 Selimiye Uskudar, 34668, Istanbul, Turkey aut Yekrek Murat Biochemistry Section, Haydarpasa Numune Training and Research Hospital, 17 Selimiye Uskudar, 34668, Istanbul, Turkey aut Muftuoglu Tolga 4th General Surgery Clinic, Haydarpasa Numune Training and Research Hospital, 17 Selimiye Uskudar, 34668, Istanbul, Turkey aut Saglam Abdullah 4th General Surgery Clinic, Haydarpasa Numune Training and Research Hospital, 17 Selimiye Uskudar, 34668, Istanbul, Turkey aut Indian Journal of Surgery Springer India 77(2015-12-01), 557-562 0972-2068 77<557 2015 77 12262 https://doi.org/10.1007/s12262-013-0921-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12262-013-0921-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Aktekin Ali 4th General Surgery Clinic, Haydarpasa Numune Training and Research Hospital, 17 Selimiye Uskudar, 34668, Istanbul, Turkey aut NATIONALLICENCE 700 1- Kazan Kazım 4th General Surgery Clinic, Haydarpasa Numune Training and Research Hospital, 17 Selimiye Uskudar, 34668, Istanbul, Turkey aut NATIONALLICENCE 700 1- Gunes Pembegul Pathology Section, Haydarpasa Numune Training and Research Hospital, 17 Selimiye Uskudar, 34668, Istanbul, Turkey aut NATIONALLICENCE 700 1- Yekrek Murat Biochemistry Section, Haydarpasa Numune Training and Research Hospital, 17 Selimiye Uskudar, 34668, Istanbul, Turkey aut NATIONALLICENCE 700 1- Muftuoglu Tolga 4th General Surgery Clinic, Haydarpasa Numune Training and Research Hospital, 17 Selimiye Uskudar, 34668, Istanbul, Turkey aut NATIONALLICENCE 700 1- Saglam Abdullah 4th General Surgery Clinic, Haydarpasa Numune Training and Research Hospital, 17 Selimiye Uskudar, 34668, Istanbul, Turkey aut NATIONALLICENCE 773 0- Indian Journal of Surgery Springer India 77(2015-12-01), 557-562 0972-2068 77<557 2015 77 12262