caa a22 4500 606247505 CHVBK 20210128101345.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s12262-013-0954-9 doi (NATIONALLICENCE)springer-10.1007/s12262-013-0954-9 Intravenous Versus Oral Antibiotic Prophylaxis Efficacy for Elective Laparoscopic Cholecystectomies: a Prospective Randomized Controlled Trial [Elektronische Daten] [A. Karaca, Haldun Gündoğdu, Mehmet Özdoğan, Eren Ersoy] The aim of the present prospective randomized controlled trial is to compare the effectiveness of intravenous and oral antibiotic prophylaxis for cost and surgical site infection in elective laparoscopic cholecystectomy. Three hundred twenty patients were split into two groups as to include 160 patients in each, and they were evaluated in a prospective and randomized fashion. While one group was subjected to 1g cefazolin via intravenous route during anesthesia induction, other group received 1g cephalexin monohydrate via oral route 1h prior to the operation. Demographic findings and operation results of the patients were compared by analyses. Our 320 patients (278 females and 42 males) received elective cholecystectomy and were followed up for a period of 6-26months. Each group had 160 patients. Both groups were similar with regard to demographic characteristics and inclusion criteria. Among all, only five (1.5%) cases demonstrated postoperative surgical site infection. Surgical site infection at postoperative period was determined in three (1.8%) cases of intravenous prophylaxis group and two (1.2%) cases of oral prophylaxis group. There was no statistically significant difference between the groups in terms of surgical site infection. Oral antibiotic prophylaxis can be used in elective laparoscopic cholecystectomy prophylaxis due to its cost-effective, reliable nature, and low surgical site infection rate. Association of Surgeons of India, 2013 Laparoscopic cholecystectomy nationallicence Antibiotic prophylaxis nationallicence Surgical site infection nationallicence Karaca A. Department of General Surgery, Ankara Atatürk Training and Research Hospital, Ankara, Turkey aut Gündoğdu Haldun Department of General Surgery, Ankara Atatürk Training and Research Hospital, Ankara, Turkey aut Özdoğan Mehmet Department of General Surgery, Ankara Atatürk Training and Research Hospital, Ankara, Turkey aut Ersoy Eren Department of General Surgery, Ankara Atatürk Training and Research Hospital, Ankara, Turkey aut Indian Journal of Surgery Springer India 77(2015-12-01), 640-644 0972-2068 77<640 2015 77 12262 https://doi.org/10.1007/s12262-013-0954-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12262-013-0954-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Karaca A. Department of General Surgery, Ankara Atatürk Training and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Gündoğdu Haldun Department of General Surgery, Ankara Atatürk Training and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Özdoğan Mehmet Department of General Surgery, Ankara Atatürk Training and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Ersoy Eren Department of General Surgery, Ankara Atatürk Training and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 773 0- Indian Journal of Surgery Springer India 77(2015-12-01), 640-644 0972-2068 77<640 2015 77 12262