caa a22 4500 606247556 CHVBK 20210128101345.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s12262-013-0845-0 doi (NATIONALLICENCE)springer-10.1007/s12262-013-0845-0 The Effect of Simvastatin on Pulmonary Damage in Experimental Peritonitis in Rats [Elektronische Daten] [Cetin Altunal, Fatih Agalar, Canan Agalar, Cagatay Daphan, Oral Saygun, Kuzey Aydinuraz, Tayfun Sahiner, Pinar Atasoy, Osman Caglayan, Sedat Dom] Statins are widely used in the treatment of hyperlipidemia, as they inhibit cholesterol synthesis. They also have anti-inflammatory, antioxidant, immunomodulatory, and positive endothelial-functional effects. It is hypothesized that simvastatin ameliorates pulmonary damage secondary to peritonitis in rats. Forty Wistar albino rats were divided into four groups. In sham group, laparotomy was the standard procedure. In simvastatin group, simvastatin was given perorally before laparotomy. In sepsis group, peritoneal sepsis was constituted by cecal ligation and puncture technique. In sepsis + simvastatin group, the procedures of simvastatin and sepsis groups were applied together. After sacrification at the 72nd hour, tissue samples from lungs were harvested for histopathological examination, wet and dry weight measurements, and tissue culture, tissue malondialdehyde, and nitric oxide tests. Blood samples were taken for C-reactive protein and whole blood count. While the malondialdehyde levels were found to be significantly higher in sepsis group, nitric oxide levels were found to be significantly lower in simvastatin + sepsis group. Alveolar hemorrhage was highest in simvastatin + sepsis group. There was no difference for C-reactive protein, leukocyte levels, and histopathological examination between any groups. The ratios of wet and dry lung weights were higher in simvastatin-given groups. Simvastatin has no positive effect in terms of lung dysfunction on experimental sepsis model. For a better understanding of the effects of simvastatin on lung injury in peritoneal sepsis, experimental models of longer duration that enable to search the effects of simvastatin beyond 3days will be more useful. Association of Surgeons of India, 2013 Simvastatin nationallicence HMG-CoA reductase inhibitor nationallicence Cecal ligation puncture nationallicence MDA nationallicence NO nationallicence Altunal Cetin Department of General Surgery, Muş State Hospital, Muş, Turkey aut Agalar Fatih Department of General Surgery, Anadolu Medical Center, Kocaeli, Turkey aut Agalar Canan Departments of Infectious Diseases, Kırıkkale University School of Medicine, Kırıkkale, Turkey aut Daphan Cagatay Departments of General Surgery, Kırıkkale University School of Medicine, Kırıkkale, Turkey aut Saygun Oral Departments of General Surgery, Kırıkkale University School of Medicine, Kırıkkale, Turkey aut Aydinuraz Kuzey Departments of General Surgery, Kırıkkale University School of Medicine, Kırıkkale, Turkey aut Sahiner Tayfun Department of General Surgery, Kırşehir State Hospital, Kırşehir, Turkey aut Atasoy Pinar Departments of Pathology, Kırıkkale University School of Medicine, Kırıkkale, Turkey aut Caglayan Osman Departments of Biochemistry, Kırıkkale University School of Medicine, Kırıkkale, Turkey aut Dom Sedat Departments of General Surgery, Kırıkkale University School of Medicine, Kırıkkale, Turkey aut Indian Journal of Surgery Springer India 77(2015-12-01), 370-375 0972-2068 77<370 2015 77 12262 https://doi.org/10.1007/s12262-013-0845-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12262-013-0845-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Altunal Cetin Department of General Surgery, Muş State Hospital, Muş, Turkey aut NATIONALLICENCE 700 1- Agalar Fatih Department of General Surgery, Anadolu Medical Center, Kocaeli, Turkey aut NATIONALLICENCE 700 1- Agalar Canan Departments of Infectious Diseases, Kırıkkale University School of Medicine, Kırıkkale, Turkey aut NATIONALLICENCE 700 1- Daphan Cagatay Departments of General Surgery, Kırıkkale University School of Medicine, Kırıkkale, Turkey aut NATIONALLICENCE 700 1- Saygun Oral Departments of General Surgery, Kırıkkale University School of Medicine, Kırıkkale, Turkey aut NATIONALLICENCE 700 1- Aydinuraz Kuzey Departments of General Surgery, Kırıkkale University School of Medicine, Kırıkkale, Turkey aut NATIONALLICENCE 700 1- Sahiner Tayfun Department of General Surgery, Kırşehir State Hospital, Kırşehir, Turkey aut NATIONALLICENCE 700 1- Atasoy Pinar Departments of Pathology, Kırıkkale University School of Medicine, Kırıkkale, Turkey aut NATIONALLICENCE 700 1- Caglayan Osman Departments of Biochemistry, Kırıkkale University School of Medicine, Kırıkkale, Turkey aut NATIONALLICENCE 700 1- Dom Sedat Departments of General Surgery, Kırıkkale University School of Medicine, Kırıkkale, Turkey aut NATIONALLICENCE 773 0- Indian Journal of Surgery Springer India 77(2015-12-01), 370-375 0972-2068 77<370 2015 77 12262