caa a22 4500 606247726 CHVBK 20210128101346.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s12262-013-0899-z doi (NATIONALLICENCE)springer-10.1007/s12262-013-0899-z Gastrointestinal Stromal Tumours: Review of 150 Cases from a Single Centre [Elektronische Daten] [Myla Yacob, Samarasam Inian, Chandran Sudhakar] Gastrointestinal stromal tumours (GIST) are the most common mesenchymal tumours of the gastrointestinal tract. They constitute a significant percentage ranging from 1-2% of all the gastrointestinal neoplasms [11]. Knowledge on the molecular biology and behavior of these tumours is still not very clear. The clinicopathologial features are variable and surgical resection with chemotherapy is the main modality of treatment. We have retrospectively analyzed the clinicopathological features, treatment and prognosis of 150 patients managed in the Department of Surgery. Retrospective review of the records of 150 patients diagnosed with gastrointestinal stromal tumours and managed during the period January 2006 to December 2011. Clinicopathological features, immunohistochemistry, mitotic index, surgical resection adjuvant chemotherapy and survival analyzed. One hundred and fifty patients diagnosed with GIST and treated were reviewed. Ninety five of them were males (63.3%). The tumour was most commonly seen during the fourth and fifth decades of life. Abdominal pain (52%), intestinal bleeding (40%) and abdominal mass (25%) were the common clinical symptoms. Sixty percent of the tumours (90/150) were located in the stomach followed by small bowel (20%) and duodenum (14.6%). One hundred and thirty-five patients underwent excision of the tumour and five patients had multi organ resection of the adjacent organs like spleen, tail of the pancreas and kidney. Fifteen patients (10%) received neoadjuvant Imatinib for down staging of the tumour prior to surgery. The tumour size ranged from 1 to 34cm. One third of the tumours (42/150) belonged to the high-grade category. KIT protein (CD117) was positive in 90 %( 135/150), while CD34 was positive in 50% (74/150) of tumours. Majority of the patients with high and intermediate-risk category received adjuvant Imatinib (65/77). Seventeen patients (11.3%) developed recurrence of the tumour on follow-up and rest of the patients had stable disease. Eight of the 15 patients (53%) who had advanced disease developed recurrence of the disease over 6months to 1year. Fifteen patients died on follow-up between 2 and 5years. Gastrointestinal tumours are the most common non epithelial tumour of the GIT. GISTS are found to show a male preponderance and are common during the fourth and fifth decades. Abdominal pain and intestinal bleeding are the most common clinical presentation. Most of the tumours were located in the stomach. Surgical resection is the best modality of treatment for operable lesions. Tyrosine kinase receptor (KIT) inhibitor like imatinib is used for adjuvant treatment. Regular follow-up with ultra sonogram or computed tomogram helps in diagnosing disease recurrence. Association of Surgeons of India, 2013 Gastrointestinal stromal tumours nationallicence Surgical resection nationallicence Chemotherapy nationallicence Prognosis nationallicence Yacob Myla Department of Surgery Unit 3, Christian Medical College and Hospital, 632004, Vellore, Tamilnadu, India aut Inian Samarasam Department of Surgery Unit 3, Christian Medical College and Hospital, 632004, Vellore, Tamilnadu, India aut Sudhakar Chandran Department of Surgery Unit 3, Christian Medical College and Hospital, 632004, Vellore, Tamilnadu, India aut Indian Journal of Surgery Springer India 77(2015-12-01), 505-510 0972-2068 77<505 2015 77 12262 https://doi.org/10.1007/s12262-013-0899-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12262-013-0899-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yacob Myla Department of Surgery Unit 3, Christian Medical College and Hospital, 632004, Vellore, Tamilnadu, India aut NATIONALLICENCE 700 1- Inian Samarasam Department of Surgery Unit 3, Christian Medical College and Hospital, 632004, Vellore, Tamilnadu, India aut NATIONALLICENCE 700 1- Sudhakar Chandran Department of Surgery Unit 3, Christian Medical College and Hospital, 632004, Vellore, Tamilnadu, India aut NATIONALLICENCE 773 0- Indian Journal of Surgery Springer India 77(2015-12-01), 505-510 0972-2068 77<505 2015 77 12262